| 出版应用/物种/样本/稀释 | 参考文献 |
|---|
| Warnes G. Flow cytometric detection of hyper-polarized mitochondria in regulated and accidental cell death processes. Apoptosis. 2020;25:548-557 pubmed 出版商 |
- 免疫组化-石蜡切片; 小鼠; 1:1000; 图 4b
| Okawa A, Morioka T, Imaoka T, Kakinuma S, Matsumoto Y. Differential expression of DNA-dependent protein kinase catalytic subunit in the brain of neonatal mice and young adult mice. Proc Jpn Acad Ser B Phys Biol Sci. 2020;96:171-179 pubmed 出版商 |
- 免疫组化-石蜡切片; 嗜热四膜虫; 1:200; 图 2a
| Tian M, Loidl J. A chromatin-associated protein required for inducing and limiting meiotic DNA double-strand break formation. Nucleic Acids Res. 2018;46:11822-11834 pubmed 出版商 |
- 免疫组化-石蜡切片; 小鼠; 1:100; 表 1
| Fu C, Begum K, Jordan P, He Y, Overbeek P. Dearth and Delayed Maturation of Testicular Germ Cells in Fanconi Anemia E Mutant Male Mice. PLoS ONE. 2016;11:e0159800 pubmed 出版商 |
| Bravo M, Nicolini F, Starowicz K, Barroso S, Calés C, Aguilera A, et al. Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression. J Cell Sci. 2015;128:3660-71 pubmed 出版商 |
| Maya Mendoza A, Ostrakova J, Kosar M, Hall A, Duskova P, Mistrik M, et al. Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress. Mol Oncol. 2015;9:601-16 pubmed 出版商 |
| Orim F, Bychkov A, Shimamura M, Nakashima M, Ito M, Matsuse M, et al. Thyrotropin signaling confers more aggressive features with higher genomic instability on BRAF(V600E)-induced thyroid tumors in a mouse model. Thyroid. 2014;24:502-10 pubmed 出版商 |
| Ganan Gomez I, Yang H, Ma F, Montalban Bravo G, Thongon N, Marchica V, et al. Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy. Nat Med. 2022;28:557-567 pubmed 出版商 |
| Pelicci S, Furia L, Scanarini M, Pelicci P, Lanzano L, Faretta M. Novel Tools to Measure Single Molecules Colocalization in Fluorescence Nanoscopy by Image Cross Correlation Spectroscopy. Nanomaterials (Basel). 2022;12: pubmed 出版商 |
| Switonski P, Delaney J, Bartelt L, Niu C, Ramos Zapatero M, Spann N, et al. Altered H3 histone acetylation impairs high-fidelity DNA repair to promote cerebellar degeneration in spinocerebellar ataxia type 7. Cell Rep. 2021;37:110062 pubmed 出版商 |
| Sakata R, Niwa K, Ugarte La Torre D, Gu C, Tahara E, Takada S, et al. Opening of cohesin's SMC ring is essential for timely DNA replication and DNA loop formation. Cell Rep. 2021;35:108999 pubmed 出版商 |
| Swift M, Beishline K, Flashner S, Azizkhan Clifford J. DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1. Cell Rep. 2021;34:108840 pubmed 出版商 |
| Cuella Martin R, Hayward S, Fan X, Chen X, Huang J, Taglialatela A, et al. Functional interrogation of DNA damage response variants with base editing screens. Cell. 2021;184:1081-1097.e19 pubmed 出版商 |
| Murray Nerger L, Justice J, Rekapalli P, Hutton J, Cristea I. Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair. Nucleic Acids Res. 2021;: pubmed 出版商 |
| Hopp A, Teloni F, Bisceglie L, Gondrand C, Raith F, Nowak K, et al. Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation. Mol Cell. 2021;81:340-354.e5 pubmed 出版商 |
| Gavande N, VanderVere Carozza P, Pawelczak K, Mendoza Munoz P, Vernon T, HANAKAHI L, et al. Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku-DNA interaction. Nucleic Acids Res. 2020;48:11536-11550 pubmed 出版商 |
| Xu Y, Lin Y, Luo Y, Yang Y, Long B, Fang Z, et al. RAD52 aptamer regulates DNA damage repair and STAT3 in BRCA1/BRCA2‑deficient human acute myeloid leukemia. Oncol Rep. 2020;44:1455-1466 pubmed 出版商 |
| Prendergast L, McClurg U, Hristova R, Berlinguer Palmini R, Greener S, Veitch K, et al. Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability. Nat Commun. 2020;11:4534 pubmed 出版商 |
| Wang C, Chen Z, Su D, Tang M, Nie L, Zhang H, et al. C17orf53 is identified as a novel gene involved in inter-strand crosslink repair. DNA Repair (Amst). 2020;95:102946 pubmed 出版商 |
| Gatti M, Imhof R, Huang Q, Baudis M, Altmeyer M. The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency. Cell Rep. 2020;32:107985 pubmed 出版商 |
| Mlcochova P, Winstone H, Zuliani Alvarez L, Gupta R. TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages. Cell Rep. 2020;30:3972-3980.e5 pubmed 出版商 |
| Delaney J, Patel C, Bapat J, Jones C, Ramos Zapatero M, Ortell K, et al. Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors. PLoS Genet. 2020;16:e1008558 pubmed 出版商 |
| Stobezki R, Titus S, Halicka D, Darzynkiewicz Z, Oktay K. Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate. Reprod Sci. 2020;27:940-953 pubmed 出版商 |
| Nguyen T, Kabotyanski E, Reineke L, Shao J, Xiong F, Lee J, et al. The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nucleic Acids Res. 2020;48:2621-2642 pubmed 出版商 |
| Michelena J, Gatti M, Teloni F, Imhof R, Altmeyer M. Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions. J Cell Biol. 2019;218:2865-2875 pubmed 出版商 |
| Garg J, Saettone A, Nabeel Shah S, Cadorin M, Ponce M, Marquez S, et al. The Med31 Conserved Component of the Divergent Mediator Complex in Tetrahymena thermophila Participates in Developmental Regulation. Curr Biol. 2019;29:2371-2379.e6 pubmed 出版商 |
| Qin Y, Sekine I, Hanazono M, Morinaga T, Fan M, Takiguchi Y, et al. AMPK activation induced in pemetrexed-treated cells is associated with development of drug resistance independently of target enzyme expression. Mol Oncol. 2019;13:1419-1432 pubmed 出版商 |
| Kohutova A, Raška J, Krutá M, Šeneklová M, Bárta T, Fojtik P, et al. Ligase 3-mediated end-joining maintains genome stability of human embryonic stem cells. FASEB J. 2019;33:6778-6788 pubmed 出版商 |
| Zhong B, Shingyoji M, Hanazono M, Nguyễn T, Morinaga T, Tada Y, et al. A p53-stabilizing agent, CP-31398, induces p21 expression with increased G2/M phase through the YY1 transcription factor in esophageal carcinoma defective of the p53 pathway. Am J Cancer Res. 2019;9:79-93 pubmed |
| Wang Z, Song Y, Li S, Kurian S, Xiang R, Chiba T, et al. DNA polymerase θ (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse. J Biol Chem. 2019;294:3909-3919 pubmed 出版商 |
| Teloni F, Michelena J, Lezaja A, Kiliç S, Ambrosi C, Menon S, et al. Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability. Mol Cell. 2019;73:670-683.e12 pubmed 出版商 |
| Saxena S, Somyajit K, Nagaraju G. XRCC2 Regulates Replication Fork Progression during dNTP Alterations. Cell Rep. 2018;25:3273-3282.e6 pubmed 出版商 |
| Maffucci P, Chavez J, Jurkiw T, O Brien P, Abbott J, Reynolds P, et al. Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies. J Clin Invest. 2018;128:5489-5504 pubmed 出版商 |
| Przetocka S, Porro A, Bolck H, Walker C, Lezaja A, Trenner A, et al. CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress. Mol Cell. 2018;72:568-582.e6 pubmed 出版商 |
| Hjorth Jensen K, Maya Mendoza A, Dalgaard N, Sigurðsson J, Bartek J, Iglesias Gato D, et al. SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability. Nucleic Acids Res. 2018;46:9484-9495 pubmed 出版商 |
| Michelena J, Lezaja A, Teloni F, Schmid T, Imhof R, Altmeyer M. Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance. Nat Commun. 2018;9:2678 pubmed 出版商 |
| Friedman J, Morisada M, Sun L, Moore E, Padget M, Hodge J, et al. Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies. J Immunother Cancer. 2018;6:59 pubmed 出版商 |
| Sang M, Nakamura M, Ogata T, Sun D, Shimozato O, Nikaido T, et al. Impact of RUNX2 gene silencing on the gemcitabine sensitivity of p53?mutated pancreatic cancer MiaPaCa?2 spheres. Oncol Rep. 2018;39:2749-2758 pubmed 出版商 |
| Perucca P, Mocchi R, Guardamagna I, Bassi E, Sommatis S, Nardo T, et al. A damaged DNA binding protein 2 mutation disrupting interaction with proliferating-cell nuclear antigen affects DNA repair and confers proliferation advantage. Biochim Biophys Acta Mol Cell Res. 2018;1865:898-907 pubmed 出版商 |
| Kwasna D, Abdul Rehman S, Natarajan J, Matthews S, Madden R, De Cesare V, et al. Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability. Mol Cell. 2018;70:150-164.e6 pubmed 出版商 |
| Massonneau J, Ouellet C, Lucien F, Dubois C, Tyler J, Boissonneault G. Suboptimal extracellular pH values alter DNA damage response to induced double-strand breaks. FEBS Open Bio. 2018;8:416-425 pubmed 出版商 |
| Mlcochova P, Caswell S, Taylor I, Towers G, Gupta R. DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages. EMBO J. 2018;37:50-62 pubmed 出版商 |
| Taglialatela A, Alvarez S, Leuzzi G, Sannino V, Ranjha L, Huang J, et al. Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers. Mol Cell. 2017;68:414-430.e8 pubmed 出版商 |
| Paculova H, Kramara J, Simečková S, Fedr R, Soucek K, Hylse O, et al. BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors. Tumour Biol. 2017;39:1010428317727479 pubmed 出版商 |
| Valianatos G, Valcikova B, Growkova K, Verlande A, Mlcochova J, Radova L, et al. A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein. PLoS ONE. 2017;12:e0185801 pubmed 出版商 |
| Yamauchi S, Zhong B, Kawamura K, Yang S, Kubo S, Shingyoji M, et al. Cytotoxicity of replication-competent adenoviruses powered by an exogenous regulatory region is not linearly correlated with the viral infectivity/gene expression or with the E1A-activating ability but is associated with the p53 genotypes. BMC Cancer. 2017;17:622 pubmed 出版商 |
| Ogata T, Nakamura M, Sang M, Yoda H, Hiraoka K, Yin D, et al. Depletion of runt-related transcription factor 2 (RUNX2) enhances SAHA sensitivity of p53-mutated pancreatic cancer cells through the regulation of mutant p53 and TAp63. PLoS ONE. 2017;12:e0179884 pubmed 出版商 |
| Akematsu T, Fukuda Y, Garg J, Fillingham J, Pearlman R, Loidl J. Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11. elife. 2017;6: pubmed 出版商 |
| Pellegrino S, Michelena J, Teloni F, Imhof R, Altmeyer M. Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin. Cell Rep. 2017;19:1819-1831 pubmed 出版商 |
| Yamauchi M, Shibata A, Suzuki K, Suzuki M, Niimi A, Kondo H, et al. Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1. Sci Rep. 2017;7:41812 pubmed 出版商 |
| Feng W, Hale C, Over R, Cokus S, Jacobsen S, Michaels S. Large-scale heterochromatin remodeling linked to overreplication-associated DNA damage. Proc Natl Acad Sci U S A. 2017;114:406-411 pubmed 出版商 |
| S Pedersen R, Karemore G, Gudjonsson T, Rask M, Neumann B, Hériché J, et al. Profiling DNA damage response following mitotic perturbations. Nat Commun. 2016;7:13887 pubmed 出版商 |
| Nyeste A, Bencsura P, Vida I, Hegyi Z, Homolya L, Fodor E, et al. Expression of the Prion Protein Family Member Shadoo Causes Drug Hypersensitivity That Is Diminished by the Coexpression of the Wild Type Prion Protein. J Biol Chem. 2016;291:4473-86 pubmed 出版商 |
| Udugama M, M Chang F, Chan F, Tang M, Pickett H, R McGhie J, et al. Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres. Nucleic Acids Res. 2015;43:10227-37 pubmed 出版商 |
| Sandoval P, Lee P, Meng X, Kapler G. Checkpoint Activation of an Unconventional DNA Replication Program in Tetrahymena. PLoS Genet. 2015;11:e1005405 pubmed 出版商 |
| Horrell S, Chalker D. LIA4 encodes a chromoshadow domain protein required for genomewide DNA rearrangements in Tetrahymena thermophila. Eukaryot Cell. 2014;13:1300-11 pubmed 出版商 |
| Zhdanova N, Draskovic I, Minina J, Karamysheva T, Novo C, Liu W, et al. Recombinogenic telomeres in diploid Sorex granarius (Soricidae, Eulipotyphla) fibroblast cells. Mol Cell Biol. 2014;34:2786-99 pubmed 出版商 |
| Crown K, Savytskyy O, Malik S, LOGSDON J, Williams R, Tainer J, et al. A mutation in the FHA domain of Coprinus cinereus Nbs1 Leads to Spo11-independent meiotic recombination and chromosome segregation. G3 (Bethesda). 2013;3:1927-43 pubmed 出版商 |
| Jha H, Upadhyay S, A J Prasad M, Lu J, Cai Q, Saha A, et al. H2AX phosphorylation is important for LANA-mediated Kaposi's sarcoma-associated herpesvirus episome persistence. J Virol. 2013;87:5255-69 pubmed 出版商 |
| Titus S, Li F, Stobezki R, Akula K, Unsal E, Jeong K, et al. Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans. Sci Transl Med. 2013;5:172ra21 pubmed 出版商 |
| Kuefner M, Brand M, Ehrlich J, Braga L, Uder M, Semelka R. Effect of antioxidants on X-ray-induced ?-H2AX foci in human blood lymphocytes: preliminary observations. Radiology. 2012;264:59-67 pubmed 出版商 |
| Yoshihara Y, Wu D, Kubo N, Sang M, Nakagawara A, Ozaki T. Inhibitory role of E2F-1 in the regulation of tumor suppressor p53 during DNA damage response. Biochem Biophys Res Commun. 2012;421:57-63 pubmed 出版商 |
| Kaul Z, Cesare A, Huschtscha L, Neumann A, Reddel R. Five dysfunctional telomeres predict onset of senescence in human cells. EMBO Rep. 2011;13:52-9 pubmed 出版商 |
| Martinelli P, Bonetti P, Sironi C, Pruneri G, Fumagalli C, Raviele P, et al. The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway. Blood. 2011;117:6617-26 pubmed 出版商 |
| Li M, Xu X, Liu Y. The SET2-RPB1 interaction domain of human RECQ5 is important for transcription-associated genome stability. Mol Cell Biol. 2011;31:2090-9 pubmed 出版商 |
| Lee J, Hirano T. RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis. J Cell Biol. 2011;192:263-76 pubmed 出版商 |
| Widodo N, Priyandoko D, Shah N, Wadhwa R, Kaul S. Selective killing of cancer cells by Ashwagandha leaf extract and its component Withanone involves ROS signaling. PLoS ONE. 2010;5:e13536 pubmed 出版商 |
| Suzuki K, Yamauchi M, Oka Y, Suzuki M, Yamashita S. A novel and simple micro-irradiation technique for creating localized DNA double-strand breaks. Nucleic Acids Res. 2010;38:e129 pubmed 出版商 |
| Massignan T, Stewart R, Biasini E, Solomon I, Bonetto V, Chiesa R, et al. A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein. J Biol Chem. 2010;285:7752-65 pubmed 出版商 |
| Loidl J, Mochizuki K. Tetrahymena meiotic nuclear reorganization is induced by a checkpoint kinase-dependent response to DNA damage. Mol Biol Cell. 2009;20:2428-37 pubmed 出版商 |
| Akbay E, Contreras C, Perera S, Sullivan J, Broaddus R, Schorge J, et al. Differential roles of telomere attrition in type I and II endometrial carcinogenesis. Am J Pathol. 2008;173:536-44 pubmed 出版商 |
| Mochizuki K, Novatchkova M, Loidl J. DNA double-strand breaks, but not crossovers, are required for the reorganization of meiotic nuclei in Tetrahymena. J Cell Sci. 2008;121:2148-58 pubmed 出版商 |
| Xiao R, Sun Y, Ding J, Lin S, Rose D, Rosenfeld M, et al. Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis. Mol Cell Biol. 2007;27:5393-402 pubmed |
