产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
Purified (azide-free) anti-β-Amyloid, 17-24
目录 :
800702
规格 :
500微升
价格 :
1083美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
4G8
反应物种 :
人类, 小鼠, 大鼠, fruit fly
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片, 抑制或激活实验
更多信息或购买 :
文章摘录数: 118
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 图 1c
Rauskolb S, Andreska T, Fries S, von Collenberg C, Blum R, Monoranu C, et al. Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment. Acta Neuropathol Commun. 2022;10:68 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 7a
  • 免疫组化-石蜡切片; 小鼠; 图 6a
Honarpisheh P, Reynolds C, Blasco Conesa M, Moruno Manchon J, Putluri N, Bhattacharjee M, et al. Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-β in Tg2576 Mice. Int J Mol Sci. 2020;21: pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:1000; 图 s6e
Yan T, Liang J, Gao J, Wang L, Fujioka H, Zhu X, et al. FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease. Nat Commun. 2020;11:411 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 3c
Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed 出版商
  • 免疫组化-自由浮动切片; 人类; 1:5000
Braak H, Del Tredici K. From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex. J Neuropathol Exp Neurol. 2020;79:163-175 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:2000; 图 s8g
Bhattarai P, Cosacak M, Mashkaryan V, Demir S, Popova S, Govindarajan N, et al. Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain. PLoS Biol. 2020;18:e3000585 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 1b
Smith R, Pawlik D, Nilsson C, Englund E, Hansson O. [18F]Flortaucipir distinguishes Alzheimer's disease from progressive supranuclear palsy pathology in a mixed-pathology case. Acta Neuropathol. 2020;139:411-413 pubmed 出版商
  • 免疫组化-冰冻切片; fruit fly ; 1:500; 图 3c
Bergkvist L, Du Z, Elovsson G, Appelqvist H, Itzhaki L, Kumita J, et al. Mapping pathogenic processes contributing to neurodegeneration in Drosophila models of Alzheimer's disease. FEBS Open Bio. 2020;10:338-350 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:4000; 图 2b
Pires G, McElligott S, Drusinsky S, Halliday G, Potier M, Wisniewski T, et al. Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies. Acta Neuropathol Commun. 2019;7:195 pubmed 出版商
  • 免疫组化; 人类; 1:9,000; 表 2
Yu L, Boyle P, Dawe R, Bennett D, Arfanakis K, Schneider J. Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons. Neurology. 2020;94:e142-e152 pubmed 出版商
  • 免疫组化; 小鼠; 图 3c
Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed 出版商
  • 免疫细胞化学; 大鼠; 图 s4b
Latina V, Caioli S, Zona C, Ciotti M, Amadoro G, Calissano P. Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons. Front Cell Neurosci. 2017;11:68 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 1a
Guillot Sestier M, Weitz T, Town T. Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease. J Vis Exp. 2016;: pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:4000; 图 6
Noy S, Krawitz S, Del Bigio M. Chronic Traumatic Encephalopathy-Like Abnormalities in a Routine Neuropathology Service. J Neuropathol Exp Neurol. 2016;75:1145-1154 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:2000; 图 3
Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, et al. Revisiting rodent models: Octodon degus as Alzheimer's disease model?. Acta Neuropathol Commun. 2016;4:91 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:1000; 图 3b
  • 免疫组化-石蜡切片; 小鼠; 1:1000; 图 3b
  • 免疫印迹; 小鼠; 1:2000; 图 st7
  • 免疫组化-自由浮动切片; 人类; 1:1000; 图 7c
  • 免疫组化-石蜡切片; 人类; 1:1000; 图 7c
Pajares M, Jiménez Moreno N, García Yagüe A, Escoll M, De Ceballos M, Van Leuven F, et al. Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Autophagy. 2016;12:1902-1916 pubmed
  • 免疫组化-石蜡切片; 人类; 1:500; 图 2
Shively S, Horkayne Szakaly I, Jones R, Kelly J, Armstrong R, Perl D. Characterisation of interface astroglial scarring in the human brain after blast exposure: a post-mortem case series. Lancet Neurol. 2016;15:944-953 pubmed 出版商
  • 抑制或激活实验; 人类; 图 3
  • 免疫组化; 人类; 图 2
Kumar D, Choi S, Washicosky K, Eimer W, Tucker S, Ghofrani J, et al. Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease. Sci Transl Med. 2016;8:340ra72 pubmed 出版商
  • 免疫沉淀; 人类; 1:500-1:2500; 图 1H
Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn P, Kremmer E, et al. Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease. EMBO Mol Med. 2016;8:458-65 pubmed 出版商
  • 免疫沉淀; 人类; 图 4
Reinert J, Richard B, Klafki H, Friedrich B, Bayer T, Wiltfang J, et al. Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models. Acta Neuropathol Commun. 2016;4:24 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠; 1:2500; 图 2
  • 免疫印迹; 小鼠; 图 1
Müller Schiffmann A, Herring A, Abdel Hafiz L, Chepkova A, Schäble S, Wedel D, et al. Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity. Brain. 2016;139:509-25 pubmed 出版商
  • 免疫组化; 小鼠; 图 2i
  • 免疫印迹; 小鼠; 图 2f
Tapia Rojas C, Lindsay C, Montecinos Oliva C, Arrázola M, Retamales R, Bunout D, et al. Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice. Mol Neurodegener. 2015;10:62 pubmed 出版商
  • 免疫组化; 小鼠; 1:250; 图 5
  • 免疫组化; 人类; 1:250; 图 5
Xu G, Ran Y, Fromholt S, Fu C, Yachnis A, Golde T, et al. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathol Commun. 2015;3:72 pubmed 出版商
  • 免疫沉淀; 小鼠
Howell M, Bailey L, Cozart M, Gannon B, Gottschall P. Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice. Acta Neuropathol Commun. 2015;3:54 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 表 3
Keable A, Fenna K, Yuen H, Johnston D, Smyth N, Smith C, et al. Deposition of amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy. Biochim Biophys Acta. 2016;1862:1037-46 pubmed 出版商
  • 免疫组化; 人类; 表 1
Montine T, Monsell S, Beach T, Bigio E, Bu Y, Cairns N, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimers Dement. 2016;12:164-169 pubmed 出版商
  • 免疫组化; 人类; 图 3
Lutzenberger M, Burwinkel M, Riemer C, Bode V, Baier M. Ablation of CCAAT/Enhancer-Binding Protein Delta (C/EBPD): Increased Plaque Burden in a Murine Alzheimer's Disease Model. PLoS ONE. 2015;10:e0134228 pubmed 出版商
  • 免疫组化; 人类; 1:500; 图 2
Tousseyn T, Bajsarowicz K, Sánchez H, Gheyara A, Oehler A, Geschwind M, et al. Prion Disease Induces Alzheimer Disease-Like Neuropathologic Changes. J Neuropathol Exp Neurol. 2015;74:873-88 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
Tan X, Xue Y, Ma T, Wang X, Li J, Lan L, et al. Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment. Mol Neurodegener. 2015;10:24 pubmed 出版商
  • 免疫组化; 人类; 1:500
Iacono D, Geraci Erck M, Peng H, Rabin M, Kurlan R. Reduced Number of Pigmented Neurons in the Substantia Nigra of Dystonia Patients? Findings from Extensive Neuropathologic, Immunohistochemistry, and Quantitative Analyses. Tremor Other Hyperkinet Mov (N Y). 2015;5: pubmed 出版商
  • 免疫组化-冰冻切片; 人类
Rotman M, Welling M, van den Boogaard M, Moursel L, van der Graaf L, van Buchem M, et al. Fusion of hIgG1-Fc to 111In-anti-amyloid single domain antibody fragment VHH-pa2H prolongs blood residential time in APP/PS1 mice but does not increase brain uptake. Nucl Med Biol. 2015;42:695-702 pubmed 出版商
  • 免疫沉淀; 人类
Hernandez Guillamon M, Mawhirt S, Blais S, Montaner J, Neubert T, Rostagno A, et al. Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9. J Biol Chem. 2015;290:15078-91 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠
Leinenga G, Götz J. Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model. Sci Transl Med. 2015;7:278ra33 pubmed 出版商
  • 免疫印迹; 人类; 1:500
López González I, Schlüter A, Aso E, Garcia Esparcia P, Ansoleaga B, Llorens F, et al. Neuroinflammatory signals in Alzheimer disease and APP/PS1 transgenic mice: correlations with plaques, tangles, and oligomeric species. J Neuropathol Exp Neurol. 2015;74:319-44 pubmed 出版商
  • 免疫组化; 人类; 1:400
Jensen M, Arvaniti M, Mikkelsen J, Michalski D, Pinborg L, Härtig W, et al. Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease. Neurobiol Aging. 2015;36:1629-1638 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Vallortigara J, Rangarajan S, Whitfield D, Alghamdi A, Howlett D, Hortobágyi T, et al. Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia. F1000Res. 2014;3:108 pubmed 出版商
  • 免疫组化; 小鼠; 1:150
Fine J, Renner D, Forsberg A, Cameron R, Galick B, Le C, et al. Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation. Neurosci Lett. 2015;584:362-7 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Thomzig A, Wagenführ K, Daus M, Joncic M, Schulz Schaeffer W, Thanheiser M, et al. Decontamination of medical devices from pathological amyloid-?-, tau- and ?-synuclein aggregates. Acta Neuropathol Commun. 2014;2:151 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:1000
Joshi G, Gan K, Johnson D, Johnson J. Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy. Neurobiol Aging. 2015;36:664-79 pubmed 出版商
  • 免疫组化-自由浮动切片; 大鼠; 1:200
Forny Germano L, Lyra e Silva N, Batista A, Brito Moreira J, Gralle M, Boehnke S, et al. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci. 2014;34:13629-43 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:250
Lee S, Xu G, Jay T, Bhatta S, Kim K, Jung S, et al. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. J Neurosci. 2014;34:12538-46 pubmed 出版商
  • 免疫组化; 小鼠; 1 ug/ml
  • 酶联免疫吸附测定; 小鼠
Hanenberg M, McAfoose J, Kulic L, Welt T, Wirth F, Parizek P, et al. Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease. J Biol Chem. 2014;289:27080-9 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:1000
Whitfield D, Vallortigara J, Alghamdi A, Howlett D, Hortobagyi T, Johnson M, et al. Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment. Neurobiol Aging. 2014;35:2836-2844 pubmed 出版商
  • 免疫沉淀; 人类
  • 酶联免疫吸附测定; 人类
  • 免疫印迹; 人类
Toyn J, Thompson L, Lentz K, Meredith J, Burton C, Sankaranararyanan S, et al. Identification and Preclinical Pharmacology of the ?-Secretase Modulator BMS-869780. Int J Alzheimers Dis. 2014;2014:431858 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:500
Fu Y, Rusznák Z, Kwok J, Kim W, Paxinos G. Age-dependent alterations of the hippocampal cell composition and proliferative potential in the hA?PPSwInd-J20 mouse. J Alzheimers Dis. 2014;41:1177-92 pubmed 出版商
  • 免疫组化; 人类; 1:200
Hebron M, Algarzae N, Lonskaya I, Moussa C. Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and A?1-42 gene transfer models. Exp Neurol. 2014;251:127-38 pubmed 出版商
  • 免疫沉淀; 小鼠
Chapuis J, Vingtdeux V, Campagne F, Davies P, Marambaud P. Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein. Hum Mol Genet. 2011;20:2026-36 pubmed 出版商
Kaneshiro N, Komai M, Imaoka R, Ikeda A, Kamikubo Y, Saito T, et al. Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease. iScience. 2022;25:103869 pubmed 出版商
Liu S, Fan M, Xu J, Yang L, Qi C, Xia Q, et al. Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology. J Neuroinflammation. 2022;19:35 pubmed 出版商
Wang C, Huang W, Lu J, Chen H, Yu Z. TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer's Disease-Associated Pathology and Cognitive Decline. Front Pharmacol. 2021;12:763866 pubmed 出版商
Yamamoto S, Kayama T, Noguchi Shinohara M, Hamaguchi T, Yamada M, Abe K, et al. Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway. NPJ Sci Food. 2021;5:1 pubmed 出版商
Romani M, Sorrentino V, Oh C, Li H, de Lima T, Zhang H, et al. NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle. Cell Rep. 2021;34:108660 pubmed 出版商
Fassler M, Rappaport M, Cuño C, George J. Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer's disease models. J Neuroinflammation. 2021;18:19 pubmed 出版商
Prpar Mihevc S, Zakošek Pipan M, Strbenc M, Rogelj B, Majdic G. Nitrosative Stress in the Frontal Cortex From Dogs With Canine Cognitive Dysfunction. Front Vet Sci. 2020;7:573155 pubmed 出版商
Guo X, Liu Y, Morgan D, Zhao L. Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS1 Mice. Aging Dis. 2020;11:1423-1443 pubmed 出版商
Shi H, Koronyo Y, Fuchs D, Sheyn J, Wawrowsky K, Lahiri S, et al. Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer's disease. Acta Neuropathol Commun. 2020;8:202 pubmed 出版商
Natunen T, Martiskainen H, Marttinen M, Gabbouj S, Koivisto H, Kemppainen S, et al. Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques. Mol Neurodegener. 2020;15:66 pubmed 出版商
Doustar J, Rentsendorj A, Torbati T, Regis G, Fuchs D, Sheyn J, et al. Parallels between retinal and brain pathology and response to immunotherapy in old, late-stage Alzheimer's disease mouse models. Aging Cell. 2020;:e13246 pubmed 出版商
Sun F, Jiang F, Zhang N, Li H, Tian W, Liu W. Upregulation of Prickle2 Ameliorates Alzheimer's Disease-Like Pathology in a Transgenic Mouse Model of Alzheimer's Disease. Front Cell Dev Biol. 2020;8:565020 pubmed 出版商
Mo D, Li X, Raabe C, Rozhdestvensky T, Skryabin B, Brosius J. Circular RNA Encoded Amyloid Beta peptides-A Novel Putative Player in Alzheimer's Disease. Cells. 2020;9: pubmed 出版商
Guan Z, Chen Z, Fu S, Dai L, Shen Y. Progranulin Administration Attenuates β-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis. Front Cell Neurosci. 2020;14:260 pubmed 出版商
Lo Cascio F, Garcia S, Montalbano M, Puangmalai N, McAllen S, Pace A, et al. Modulating disease-relevant tau oligomeric strains by small molecules. J Biol Chem. 2020;295:14807-14825 pubmed 出版商
Puzzo D, Argyrousi E, Staniszewski A, Zhang H, Calcagno E, Zuccarello E, et al. Tau is not necessary for amyloid-β-induced synaptic and memory impairments. J Clin Invest. 2020;130:4831-4844 pubmed 出版商
Kim S, Nam Y, Kim C, Lee H, Hong S, Kim H, et al. Neuroprotective and Anti-Inflammatory Effects of Low-Moderate Dose Ionizing Radiation in Models of Alzheimer's Disease. Int J Mol Sci. 2020;21: pubmed 出版商
Rayaprolu S, Gao T, Xiao H, Ramesha S, Weinstock L, Shah J, et al. Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer's disease. Mol Neurodegener. 2020;15:28 pubmed 出版商
Xu G, Fromholt S, Chakrabarty P, Zhu F, Liu X, Pace M, et al. Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis. Acta Neuropathol Commun. 2020;8:43 pubmed 出版商
Shi H, Koronyo Y, Rentsendorj A, Regis G, Sheyn J, Fuchs D, et al. Identification of early pericyte loss and vascular amyloidosis in Alzheimer's disease retina. Acta Neuropathol. 2020;139:813-836 pubmed 出版商
Meilandt W, Ngu H, Gogineni A, Lalehzadeh G, Lee S, Srinivasan K, et al. Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model. J Neurosci. 2020;40:1956-1974 pubmed 出版商
Jäkel L, Biemans E, Klijn C, Kuiperij H, Verbeek M. Reduced Influence of apoE on Aβ43 Aggregation and Reduced Vascular Aβ43 Toxicity as Compared with Aβ40 and Aβ42. Mol Neurobiol. 2020;57:2131-2141 pubmed 出版商
Elmer B, Swanson K, Bangari D, Piepenhagen P, Roberts E, Taksir T, et al. Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer's disease. PLoS ONE. 2019;14:e0226245 pubmed 出版商
Song J, Malampati S, Zeng Y, Durairajan S, Yang C, Tong B, et al. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. Aging Cell. 2019;:e13069 pubmed 出版商
Iacono D, Lee P, Edlow B, Gray N, Fischl B, Kenney K, et al. Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity. J Neuropathol Exp Neurol. 2020;79:144-162 pubmed 出版商
Trambauer J, Rodríguez Sarmiento R, Fukumori A, Feederle R, Baumann K, Steiner H. Aβ43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation. EMBO Rep. 2020;21:e47996 pubmed 出版商
Carrillo Jimenez A, Deniz O, Niklison Chirou M, Ruiz R, Bezerra Salomão K, Stratoulias V, et al. TET2 Regulates the Neuroinflammatory Response in Microglia. Cell Rep. 2019;29:697-713.e8 pubmed 出版商
Jäkel L, Boche D, Nicoll J, Verbeek M. Aβ43 in human Alzheimer's disease: effects of active Aβ42 immunization. Acta Neuropathol Commun. 2019;7:141 pubmed 出版商
Kim S, Nam Y, Jeong Y, Park H, Lee S, Shin S, et al. Topographical Visualization of the Reciprocal Projection between the Medial Septum and the Hippocampus in the 5XFAD Mouse Model of Alzheimer's Disease. Int J Mol Sci. 2019;20: pubmed 出版商
Ezpeleta J, Baudouin V, Arellano Anaya Z, Boudet Devaud F, Pietri M, Baudry A, et al. Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation. Nat Commun. 2019;10:3442 pubmed 出版商
Wang Z, Xiang J, Liu X, Yu S, Manfredsson F, Sandoval I, et al. Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease. Cell Rep. 2019;28:655-669.e5 pubmed 出版商
Zhao P, Qian X, Nie Y, Sun N, Wang Z, Wu J, et al. Neuropeptide S Ameliorates Cognitive Impairment of APP/PS1 Transgenic Mice by Promoting Synaptic Plasticity and Reducing Aβ Deposition. Front Behav Neurosci. 2019;13:138 pubmed 出版商
Prpar Mihevc S, Majdic G. Canine Cognitive Dysfunction and Alzheimer's Disease - Two Facets of the Same Disease?. Front Neurosci. 2019;13:604 pubmed 出版商
Harper M, Hedberg Buenz A, Herlein J, Abrahamson E, Anderson M, Kuehn M, et al. Blast-Mediated Traumatic Brain Injury Exacerbates Retinal Damage and Amyloidosis in the APPswePSENd19e Mouse Model of Alzheimer's Disease. Invest Ophthalmol Vis Sci. 2019;60:2716-2725 pubmed 出版商
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Jovic M, Loncarevic Vasiljkovic N, Ivkovic S, Dinic J, Milanovic D, Zlokovic B, et al. Short-term fish oil supplementation applied in presymptomatic stage of Alzheimer's disease enhances microglial/macrophage barrier and prevents neuritic dystrophy in parietal cortex of 5xFAD mouse model. PLoS ONE. 2019;14:e0216726 pubmed 出版商
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产品信息
抗原 :
乙淀粉样蛋白17-24
Apps. Abbrev. :
IHC-P, Direct ELISA, IHC-F, ICC, IP
目录 :
800702
克隆 :
4G8
产品 :
Purified (azide-free) anti-β-Amyloid, 17-24
抗体亚型 :
Mouse IgG2b, κ
其他名称 :
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
规格 :
500微升
价格(美元) :
1083美元
反应物种 :
人类, 小鼠
克隆性 :
单克隆
宿主 :
小鼠
共轭标签/标签/标记 :
PUREAF
应用注释 :
This antibody is reactive to amino acid residues 17-24 of amyloid. The epitope lies within amino acids 18-22 of amyloid (VFFAE). 4G8 -amyloid antibody reacts to abnormally processed isoforms, as well as precursor forms. This antibody clone has been reported for use on IHC of free-floating sections in PBS containing 1% Triton incubated with 0.1 m citrate buffer (4). Additional reported applications (for the relevant formats) include: immunohistochemical staining on frozen tissue sections (IHC-F) and immunocytochemistry (ICC)
更多信息或购买 :
公司信息
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。