产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
Biotin (azide-free) anti-β-Amyloid, 17-24
目录 :
800706
规格 :
1毫升
价格 :
2284美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
生物素
克隆名称 :
4G8
反应物种 :
人类, 小鼠, 大鼠
应用 :
酶联免疫吸附测定, 免疫组化, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片
更多信息或购买 :
文章摘录数: 16
出版应用/物种/样本/稀释参考文献
  • 免疫组化-自由浮动切片; 人类; 1:5000
Braak H, Del Tredici K. From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex. J Neuropathol Exp Neurol. 2020;79:163-175 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 1b
Smith R, Pawlik D, Nilsson C, Englund E, Hansson O. [18F]Flortaucipir distinguishes Alzheimer's disease from progressive supranuclear palsy pathology in a mixed-pathology case. Acta Neuropathol. 2020;139:411-413 pubmed 出版商
  • 免疫组化; 人类; 1:9,000; 表 2
Yu L, Boyle P, Dawe R, Bennett D, Arfanakis K, Schneider J. Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons. Neurology. 2020;94:e142-e152 pubmed 出版商
  • 免疫组化; 人类; 1:400
Jensen M, Arvaniti M, Mikkelsen J, Michalski D, Pinborg L, Härtig W, et al. Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease. Neurobiol Aging. 2015;36:1629-1638 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠; 1:4000
Deng X, Li M, Ai W, He L, Lu D, Patrylo P, et al. Lipolysaccharide-Induced Neuroinflammation Is Associated with Alzheimer-Like Amyloidogenic Axonal Pathology and Dendritic Degeneration in Rats. Adv Alzheimer Dis. 2014;3:78-93 pubmed
Forgrave L, van der Gugten J, Nguyen Q, DeMarco M. Establishing pre-analytical requirements and maximizing peptide recovery in the analytical phase for mass spectrometric quantification of amyloid-β peptides 1-42 and 1-40 in CSF. Clin Chem Lab Med. 2022;60:198-206 pubmed 出版商
Do T, Capdevila C, Pradier L, Blanchard V, Lopez Grancha M, Schussler N, et al. Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model. Mol Ther Methods Clin Dev. 2020;19:58-77 pubmed 出版商
Elmer B, Swanson K, Bangari D, Piepenhagen P, Roberts E, Taksir T, et al. Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer's disease. PLoS ONE. 2019;14:e0226245 pubmed 出版商
Chen J, Long Z, Li Y, Luo M, Luo S, He G. Alteration of the Wnt/GSK3β/β‑catenin signalling pathway by rapamycin ameliorates pathology in an Alzheimer's disease model. Int J Mol Med. 2019;44:313-323 pubmed 出版商
Yao Q, Feng M, Yang B, Long Z, Luo S, Luo M, et al. Effects of ovarian hormone loss on neuritic plaques and autophagic flux in the brains of adult female APP/PS1 double-transgenic mice. Acta Biochim Biophys Sin (Shanghai). 2018;50:447-455 pubmed 出版商
Hatami A, Monjazeb S, Glabe C. The Anti-Amyloid-β Monoclonal Antibody 4G8 Recognizes a Generic Sequence-Independent Epitope Associated with α-Synuclein and Islet Amyloid Polypeptide Amyloid Fibrils. J Alzheimers Dis. 2016;50:517-25 pubmed 出版商
Hong J, Kang J, Kim D, Baik S, Kim K, Shanta S, et al. Global changes of phospholipids identified by MALDI imaging mass spectrometry in a mouse model of Alzheimer's disease. J Lipid Res. 2016;57:36-45 pubmed 出版商
Bales K, O Neill S, Pozdnyakov N, Pan F, Caouette D, Pi Y, et al. Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity. Brain. 2016;139:563-77 pubmed 出版商
Forny Germano L, Lyra e Silva N, Batista A, Brito Moreira J, Gralle M, Boehnke S, et al. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci. 2014;34:13629-43 pubmed 出版商
Watanabe H, Xia D, Kanekiyo T, Kelleher R, Shen J. Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice. J Neurosci. 2012;32:5085-96 pubmed 出版商
Townsend M, Qu Y, Gray A, Wu Z, Seto T, Hutton M, et al. Oral treatment with a gamma-secretase inhibitor improves long-term potentiation in a mouse model of Alzheimer's disease. J Pharmacol Exp Ther. 2010;333:110-9 pubmed 出版商
产品信息
抗原 :
乙淀粉样蛋白17-24
Apps. Abbrev. :
IHC-P, Direct ELISA
目录 :
800706
克隆 :
4G8
产品 :
Biotin (azide-free) anti-β-Amyloid, 17-24
抗体亚型 :
Mouse IgG2b, κ
其他名称 :
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
规格 :
1毫升
价格(美元) :
2284美元
反应物种 :
人类, 小鼠
克隆性 :
单克隆
宿主 :
小鼠
共轭标签/标签/标记 :
BIOTINAF
应用注释 :
This antibody is reactive to amino acid residues 17-24 of amyloid. The epitope lies within amino acids 18-22 of amyloid (VFFAE). 4G8 -amyloid antibody reacts to abnormally processed isoforms, as well as precursor forms. This antibody clone has been reported for use on IHC of free-floating sections in PBS containing 1% Triton incubated with 0.1 m citrate buffer (4). Additional reported applications (for the relevant formats) include: immunohistochemical staining on frozen tissue sections (IHC-F) and immunocytochemistry (ICC)
更多信息或购买 :
公司信息
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。