产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
Anti-β-Amyloid, 17-24
目录 :
800708
规格 :
50微升
价格 :
300美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
4G8
反应物种 :
人类, 小鼠
应用 :
酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片
更多信息或购买 :
文章摘录数: 21
出版应用/物种/样本/稀释参考文献
  • 免疫组化-自由浮动切片; 人类; 1:5000
Braak H, Del Tredici K. From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex. J Neuropathol Exp Neurol. 2020;79:163-175 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 1b
Smith R, Pawlik D, Nilsson C, Englund E, Hansson O. [18F]Flortaucipir distinguishes Alzheimer's disease from progressive supranuclear palsy pathology in a mixed-pathology case. Acta Neuropathol. 2020;139:411-413 pubmed 出版商
  • 免疫组化; 人类; 1:9,000; 表 2
Yu L, Boyle P, Dawe R, Bennett D, Arfanakis K, Schneider J. Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons. Neurology. 2020;94:e142-e152 pubmed 出版商
Maxwell A, Yuan P, Rivera B, Schaaf W, Mladinov M, Prasher V, et al. Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer's disease pathology in Down syndrome. Acta Neuropathol Commun. 2021;9:201 pubmed 出版商
Martin L, Bouvet P, Chounlamountri N, Watrin C, Besancon R, Pinatel D, et al. VEGF counteracts amyloid-β-induced synaptic dysfunction. Cell Rep. 2021;35:109121 pubmed 出版商
Shen Y, Hua L, Yeh C, Shen L, Ying M, Zhang Z, et al. Ultrasound with microbubbles improves memory, ameliorates pathology and modulates hippocampal proteomic changes in a triple transgenic mouse model of Alzheimer's disease. Theranostics. 2020;10:11794-11819 pubmed 出版商
Koronyo Hamaoui M, Sheyn J, Hayden E, Li S, Fuchs D, Regis G, et al. Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease. Brain. 2020;143:336-358 pubmed 出版商
Suh J, Romano D, Nitschke L, Herrick S, DiMarzio B, Dzhala V, et al. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 2019;178:1159-1175.e17 pubmed 出版商
Tang Z, Chuang K, DeCarli C, Jin L, Beckett L, Keiser M, et al. Interpretable classification of Alzheimer's disease pathologies with a convolutional neural network pipeline. Nat Commun. 2019;10:2173 pubmed 出版商
Boeddrich A, Babila J, Wiglenda T, Diez L, Jacob M, Nietfeld W, et al. The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice. Cell Chem Biol. 2019;26:109-120.e7 pubmed 出版商
Klakotskaia D, Agca C, Richardson R, Stopa E, Schachtman T, Agca Y. Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer's disease. PLoS ONE. 2018;13:e0195469 pubmed 出版商
Lee C, Daggett A, Gu X, Jiang L, Langfelder P, Li X, et al. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. 2018;97:1032-1048.e5 pubmed 出版商
Robertson A, Majchrzak M, Smith C, Gagnon R, Devidze N, Banks G, et al. Dramatic elevation in urinary amino terminal titin fragment excretion quantified by immunoassay in Duchenne muscular dystrophy patients and in dystrophin deficient rodents. Neuromuscul Disord. 2017;27:635-645 pubmed 出版商
Scholtzova H, Do E, Dhakal S, Sun Y, Liu S, Mehta P, et al. Innate Immunity Stimulation via Toll-Like Receptor 9 Ameliorates Vascular Amyloid Pathology in Tg-SwDI Mice with Associated Cognitive Benefits. J Neurosci. 2017;37:936-959 pubmed 出版商
Schaefer P, von Einem B, Walther P, Calzia E, von Arnim C. Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration. PLoS ONE. 2016;11:e0168157 pubmed 出版商
Whitehouse I, Brown D, Baybutt H, Diack A, Kellett K, Piccardo P, et al. Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-? or Pathologic Phenotype. PLoS ONE. 2016;11:e0159119 pubmed 出版商
Hatami A, Monjazeb S, Glabe C. The Anti-Amyloid-β Monoclonal Antibody 4G8 Recognizes a Generic Sequence-Independent Epitope Associated with α-Synuclein and Islet Amyloid Polypeptide Amyloid Fibrils. J Alzheimers Dis. 2016;50:517-25 pubmed 出版商
Lessard C, Cottrell B, Maruyama H, Suresh S, Golde T, Koo E. γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP). PLoS ONE. 2015;10:e0144758 pubmed 出版商
Choi S, Kim D, Kam T, Yun S, Kim S, Park H, et al. Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity. PLoS ONE. 2015;10:e0143854 pubmed 出版商
Forny Germano L, Lyra e Silva N, Batista A, Brito Moreira J, Gralle M, Boehnke S, et al. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci. 2014;34:13629-43 pubmed 出版商
Abramowski D, Rabe S, Upadhaya A, Reichwald J, Danner S, Staab D, et al. Transgenic expression of intraneuronal A?42 but not A?40 leads to cellular A? lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology. J Neurosci. 2012;32:1273-83 pubmed 出版商
产品信息
抗原 :
乙淀粉样蛋白17-24
Apps. Abbrev. :
IHC-P, Direct ELISA, IHC-F, ICC
目录 :
800708
克隆 :
4G8
产品 :
Anti-β-Amyloid, 17-24
抗体亚型 :
Mouse IgG2b, κ
其他名称 :
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
规格 :
50微升
价格(美元) :
300美元
反应物种 :
人类, 小鼠
克隆性 :
单克隆
宿主 :
小鼠
共轭标签/标签/标记 :
腹水
应用注释 :
This antibody is reactive to amino acid residues 17-24 of amyloid. The epitope lies within amino acids 18-22 of amyloid (VFFAE). 4G8 -amyloid antibody reacts to abnormally processed isoforms, as well as precursor forms. This antibody clone has been reported for use on IHC of free-floating sections in PBS containing 1% Triton incubated with 0.1 m citrate buffer (4).
更多信息或购买 :
公司信息
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。