| 出版应用/物种/样本/稀释 | 参考文献 |
|---|
| Braak H, Del Tredici K. From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex. J Neuropathol Exp Neurol. 2020;79:163-175 pubmed 出版商 |
- 免疫组化-石蜡切片; 人类; 1:500; 图 1b
| Smith R, Pawlik D, Nilsson C, Englund E, Hansson O. [18F]Flortaucipir distinguishes Alzheimer's disease from progressive supranuclear palsy pathology in a mixed-pathology case. Acta Neuropathol. 2020;139:411-413 pubmed 出版商 |
| Yu L, Boyle P, Dawe R, Bennett D, Arfanakis K, Schneider J. Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons. Neurology. 2020;94:e142-e152 pubmed 出版商 |
| Dominy S, LYNCH C, Ermini F, Benedyk M, Marczyk A, Konradi A, et al. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019;5:eaau3333 pubmed 出版商 |
- 抑制或激活实验; 人类; 图 3
- 免疫组化; 人类; 图 2
| Kumar D, Choi S, Washicosky K, Eimer W, Tucker S, Ghofrani J, et al. Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease. Sci Transl Med. 2016;8:340ra72 pubmed 出版商 |
| Reinert J, Richard B, Klafki H, Friedrich B, Bayer T, Wiltfang J, et al. Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models. Acta Neuropathol Commun. 2016;4:24 pubmed 出版商 |
- 酶联免疫吸附测定; 小鼠; 1:2500; 图 2
- 免疫印迹; 小鼠; 图 1
| Müller Schiffmann A, Herring A, Abdel Hafiz L, Chepkova A, Schäble S, Wedel D, et al. Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity. Brain. 2016;139:509-25 pubmed 出版商 |
- 免疫组化; 小鼠; 图 2i
- 免疫印迹; 小鼠; 图 2f
| Tapia Rojas C, Lindsay C, Montecinos Oliva C, Arrázola M, Retamales R, Bunout D, et al. Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice. Mol Neurodegener. 2015;10:62 pubmed 出版商 |
- 免疫组化; 人类; 1:250; 图 5
- 免疫组化; 小鼠; 1:250; 图 5
| Xu G, Ran Y, Fromholt S, Fu C, Yachnis A, Golde T, et al. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathol Commun. 2015;3:72 pubmed 出版商 |
| Howell M, Bailey L, Cozart M, Gannon B, Gottschall P. Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice. Acta Neuropathol Commun. 2015;3:54 pubmed 出版商 |
| Montine T, Monsell S, Beach T, Bigio E, Bu Y, Cairns N, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimers Dement. 2016;12:164-169 pubmed 出版商 |
| Bhatt D, Puig K, Gorr M, Wold L, Combs C. A pilot study to assess effects of long-term inhalation of airborne particulate matter on early Alzheimer-like changes in the mouse brain. PLoS ONE. 2015;10:e0127102 pubmed 出版商 |
| Rotman M, Welling M, van den Boogaard M, Moursel L, van der Graaf L, van Buchem M, et al. Fusion of hIgG1-Fc to 111In-anti-amyloid single domain antibody fragment VHH-pa2H prolongs blood residential time in APP/PS1 mice but does not increase brain uptake. Nucl Med Biol. 2015;42:695-702 pubmed 出版商 |
| Hernandez Guillamon M, Mawhirt S, Blais S, Montaner J, Neubert T, Rostagno A, et al. Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9. J Biol Chem. 2015;290:15078-91 pubmed 出版商 |
| Leinenga G, Götz J. Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model. Sci Transl Med. 2015;7:278ra33 pubmed 出版商 |
| López González I, Schlüter A, Aso E, Garcia Esparcia P, Ansoleaga B, Llorens F, et al. Neuroinflammatory signals in Alzheimer disease and APP/PS1 transgenic mice: correlations with plaques, tangles, and oligomeric species. J Neuropathol Exp Neurol. 2015;74:319-44 pubmed 出版商 |
| Jensen M, Arvaniti M, Mikkelsen J, Michalski D, Pinborg L, Härtig W, et al. Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease. Neurobiol Aging. 2015;36:1629-1638 pubmed 出版商 |
| Condello C, Yuan P, Schain A, Grutzendler J. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. Nat Commun. 2015;6:6176 pubmed 出版商 |
| Fine J, Renner D, Forsberg A, Cameron R, Galick B, Le C, et al. Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation. Neurosci Lett. 2015;584:362-7 pubmed 出版商 |
| Joshi G, Gan K, Johnson D, Johnson J. Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy. Neurobiol Aging. 2015;36:664-79 pubmed 出版商 |
| Lee S, Xu G, Jay T, Bhatta S, Kim K, Jung S, et al. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. J Neurosci. 2014;34:12538-46 pubmed 出版商 |
- 免疫组化; 小鼠; 1 ug/ml
- 酶联免疫吸附测定; 小鼠
| Hanenberg M, McAfoose J, Kulic L, Welt T, Wirth F, Parizek P, et al. Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease. J Biol Chem. 2014;289:27080-9 pubmed 出版商 |
- 免疫沉淀; 人类
- 酶联免疫吸附测定; 人类
- 免疫印迹; 人类
| Toyn J, Thompson L, Lentz K, Meredith J, Burton C, Sankaranararyanan S, et al. Identification and Preclinical Pharmacology of the ?-Secretase Modulator BMS-869780. Int J Alzheimers Dis. 2014;2014:431858 pubmed 出版商 |
| Hebron M, Algarzae N, Lonskaya I, Moussa C. Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and A?1-42 gene transfer models. Exp Neurol. 2014;251:127-38 pubmed 出版商 |
| Chapuis J, Vingtdeux V, Campagne F, Davies P, Marambaud P. Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein. Hum Mol Genet. 2011;20:2026-36 pubmed 出版商 |
| Maxwell A, Yuan P, Rivera B, Schaaf W, Mladinov M, Prasher V, et al. Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer's disease pathology in Down syndrome. Acta Neuropathol Commun. 2021;9:201 pubmed 出版商 |
| Martin L, Bouvet P, Chounlamountri N, Watrin C, Besancon R, Pinatel D, et al. VEGF counteracts amyloid-β-induced synaptic dysfunction. Cell Rep. 2021;35:109121 pubmed 出版商 |
| Shen Y, Hua L, Yeh C, Shen L, Ying M, Zhang Z, et al. Ultrasound with microbubbles improves memory, ameliorates pathology and modulates hippocampal proteomic changes in a triple transgenic mouse model of Alzheimer's disease. Theranostics. 2020;10:11794-11819 pubmed 出版商 |
| Koronyo Hamaoui M, Sheyn J, Hayden E, Li S, Fuchs D, Regis G, et al. Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease. Brain. 2020;143:336-358 pubmed 出版商 |
| Suh J, Romano D, Nitschke L, Herrick S, DiMarzio B, Dzhala V, et al. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 2019;178:1159-1175.e17 pubmed 出版商 |
| Tang Z, Chuang K, DeCarli C, Jin L, Beckett L, Keiser M, et al. Interpretable classification of Alzheimer's disease pathologies with a convolutional neural network pipeline. Nat Commun. 2019;10:2173 pubmed 出版商 |
| Boeddrich A, Babila J, Wiglenda T, Diez L, Jacob M, Nietfeld W, et al. The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice. Cell Chem Biol. 2019;26:109-120.e7 pubmed 出版商 |
| Klakotskaia D, Agca C, Richardson R, Stopa E, Schachtman T, Agca Y. Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer's disease. PLoS ONE. 2018;13:e0195469 pubmed 出版商 |
| Lee C, Daggett A, Gu X, Jiang L, Langfelder P, Li X, et al. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. 2018;97:1032-1048.e5 pubmed 出版商 |
| Robertson A, Majchrzak M, Smith C, Gagnon R, Devidze N, Banks G, et al. Dramatic elevation in urinary amino terminal titin fragment excretion quantified by immunoassay in Duchenne muscular dystrophy patients and in dystrophin deficient rodents. Neuromuscul Disord. 2017;27:635-645 pubmed 出版商 |
| Scholtzova H, Do E, Dhakal S, Sun Y, Liu S, Mehta P, et al. Innate Immunity Stimulation via Toll-Like Receptor 9 Ameliorates Vascular Amyloid Pathology in Tg-SwDI Mice with Associated Cognitive Benefits. J Neurosci. 2017;37:936-959 pubmed 出版商 |
| Schaefer P, von Einem B, Walther P, Calzia E, von Arnim C. Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration. PLoS ONE. 2016;11:e0168157 pubmed 出版商 |
| Whitehouse I, Brown D, Baybutt H, Diack A, Kellett K, Piccardo P, et al. Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-? or Pathologic Phenotype. PLoS ONE. 2016;11:e0159119 pubmed 出版商 |
| Hatami A, Monjazeb S, Glabe C. The Anti-Amyloid-β Monoclonal Antibody 4G8 Recognizes a Generic Sequence-Independent Epitope Associated with α-Synuclein and Islet Amyloid Polypeptide Amyloid Fibrils. J Alzheimers Dis. 2016;50:517-25 pubmed 出版商 |
| Lessard C, Cottrell B, Maruyama H, Suresh S, Golde T, Koo E. γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP). PLoS ONE. 2015;10:e0144758 pubmed 出版商 |
| Choi S, Kim D, Kam T, Yun S, Kim S, Park H, et al. Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity. PLoS ONE. 2015;10:e0143854 pubmed 出版商 |
| Liu P, Reed M, Kotilinek L, Grant M, Forster C, Qiang W, et al. Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration. Cell Rep. 2015;11:1760-71 pubmed 出版商 |
| Forny Germano L, Lyra e Silva N, Batista A, Brito Moreira J, Gralle M, Boehnke S, et al. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci. 2014;34:13629-43 pubmed 出版商 |
| Abramowski D, Rabe S, Upadhaya A, Reichwald J, Danner S, Staab D, et al. Transgenic expression of intraneuronal A?42 but not A?40 leads to cellular A? lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology. J Neurosci. 2012;32:1273-83 pubmed 出版商 |
| Chapuis J, Vingtdeux V, Capiralla H, Davies P, Marambaud P. Gas1 interferes with A?PP trafficking by facilitating the accumulation of immature A?PP in endoplasmic reticulum-associated raft subdomains. J Alzheimers Dis. 2012;28:127-35 pubmed 出版商 |
