产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
Purified anti-Neurofilament H (NF-H), Phosphorylated
目录 :
801601
规格 :
100微升
价格 :
276美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
SMI 31
反应物种 :
日本大米鱼, 人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 82
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 图 1g
Powers R, Daza R, Koehler A, Courchet J, Calabrese B, Hevner R, et al. Growth cone macropinocytosis of neurotrophin receptor and neuritogenesis are regulated by neuron navigator 1. Mol Biol Cell. 2022;33:ar64 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
Papazian I, Tsoukala E, Boutou A, Karamita M, Kambas K, Iliopoulou L, et al. Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice. J Neuroinflammation. 2021;18:222 pubmed 出版商
  • 免疫组化; 小鼠; 1:1500; 图 1b
Erwig M, Patzig J, Steyer A, Dibaj P, Heilmann M, Heilmann I, et al. Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin. elife. 2019;8: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:500; 图 8a
Kubo A, Misonou H, Matsuyama M, Nomori A, Wada Kakuda S, Takashima A, et al. Distribution of endogenous normal tau in the mouse brain. J Comp Neurol. 2019;527:985-998 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3A
Chen S, Sun J, Zhao G, Guo A, Chen Y, Fu R, et al. Liraglutide Improves Water Maze Learning and Memory Performance While Reduces Hyperphosphorylation of Tau and Neurofilaments in APP/PS1/Tau Triple Transgenic Mice. Neurochem Res. 2017;42:2326-2335 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:1500; 图 2
Patzig J, Erwig M, Tenzer S, Kusch K, Dibaj P, Mobius W, et al. Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction. elife. 2016;5: pubmed 出版商
  • 免疫组化; 大鼠; 1:1000; 图 2
Visavadiya N, Springer J. Altered Cerebellar Circuitry following Thoracic Spinal Cord Injury in Adult Rats. Neural Plast. 2016;2016:8181393 pubmed 出版商
  • 免疫组化; 小鼠; 图 st1
Ku T, Swaney J, Park J, Albanese A, Murray E, Cho J, et al. Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues. Nat Biotechnol. 2016;34:973-81 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:1000; 图 1
Li T, Braunstein K, Zhang J, Lau A, Sibener L, Deeble C, et al. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nat Commun. 2016;7:12082 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:500; 图 5
Allodi I, Comley L, Nichterwitz S, Nizzardo M, Simone C, Benitez J, et al. Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS. Sci Rep. 2016;6:25960 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000; 图 2
Traka M, Podojil J, McCarthy D, Miller S, Popko B. Oligodendrocyte death results in immune-mediated CNS demyelination. Nat Neurosci. 2016;19:65-74 pubmed 出版商
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Wagener R, Witte M, Guy J, Mingo Moreno N, Kügler S, Staiger J. Thalamocortical Connections Drive Intracortical Activation of Functional Columns in the Mislaminated Reeler Somatosensory Cortex. Cereb Cortex. 2016;26:820-37 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
Angliker N, Burri M, Zaichuk M, Fritschy J, Rüegg M. mTORC1 and mTORC2 have largely distinct functions in Purkinje cells. Eur J Neurosci. 2015;42:2595-612 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 3
Inoue K, Fujimura H, Ueda K, Matsumura T, Itoh K, Sakoda S. An autopsy case of neuronal intermediate filament inclusion disease with regard to immunophenotypic and topographical analysis of the neuronal inclusions. Neuropathology. 2015;35:545-52 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:5000
Heinen A, Beyer F, Tzekova N, Hartung H, Küry P. Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype. Exp Neurol. 2015;271:25-35 pubmed 出版商
  • 免疫印迹; 日本大米鱼; 1:1000; 图 3
Uemura N, Koike M, Ansai S, Kinoshita M, Ishikawa Fujiwara T, Matsui H, et al. Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein. PLoS Genet. 2015;11:e1005065 pubmed 出版商
  • 免疫细胞化学; 人类
Radonjić N, Memi F, Ortega J, Glidden N, Zhan H, Zecevic N. The Role of Sonic Hedgehog in the Specification of Human Cortical Progenitors In Vitro. Cereb Cortex. 2016;26:131-43 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠; 1:500
Ribas V, Schnepf B, Challagundla M, Koch J, Bahr M, Lingor P. Early and sustained activation of autophagy in degenerating axons after spinal cord injury. Brain Pathol. 2015;25:157-70 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 3
Calliari A, Bobba N, Escande C, Chini E. Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner. Exp Neurol. 2014;251:91-100 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:1000
Chen J, Mizushige T, Nishimune H. Active zone density is conserved during synaptic growth but impaired in aged mice. J Comp Neurol. 2012;520:434-52 pubmed 出版商
  • 免疫组化; 大鼠; 1:1,000
Petralia R, Schwartz C, Wang Y, Mattson M, Yao P. Subcellular localization of Patched and Smoothened, the receptors for Sonic hedgehog signaling, in the hippocampal neuron. J Comp Neurol. 2011;519:3684-99 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:1000
Zurolo E, Iyer A, Maroso M, Carbonell C, Anink J, Ravizza T, et al. Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development. Brain. 2011;134:1015-32 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:200
  • 免疫印迹; 大鼠; 1:2000
Chen H, Liu B, Neufeld A. Epidermal growth factor receptor in adult retinal neurons of rat, mouse, and human. J Comp Neurol. 2007;500:299-310 pubmed
Bishop R, Won S, Irvine K, Basu J, Rome E, Swanson R. Blast-induced axonal degeneration in the rat cerebellum in the absence of head movement. Sci Rep. 2022;12:143 pubmed 出版商
Scaramuzzino C, Cuoc E, Pla P, Humbert S, Saudou F. Calcineurin and huntingtin form a calcium-sensing machinery that directs neurotrophic signals to the nucleus. Sci Adv. 2022;8:eabj8812 pubmed 出版商
Johari M, Sarparanta J, Vihola A, Jonson P, Savarese M, Jokela M, et al. Missense mutations in small muscle protein X-linked (SMPX) cause distal myopathy with protein inclusions. Acta Neuropathol. 2021;142:375-393 pubmed 出版商
McGonigal R, Barrie J, Yao D, Black L, McLaughlin M, Willison H. Neuronally expressed a-series gangliosides are sufficient to prevent the lethal age-dependent phenotype in GM3-only expressing mice. J Neurochem. 2021;158:217-232 pubmed 出版商
Maggiore J, Burrell J, Browne K, Katiyar K, Laimo F, Ali Z, et al. Tissue engineered axon-based "living scaffolds" promote survival of spinal cord motor neurons following peripheral nerve repair. J Tissue Eng Regen Med. 2020;14:1892-1907 pubmed 出版商
Pérez Luz S, Loría F, Katsu Jiménez Y, Oberdoerfer D, Yang O, Lim F, et al. Altered Secretome and ROS Production in Olfactory Mucosa Stem Cells Derived from Friedreich's Ataxia Patients. Int J Mol Sci. 2020;21: pubmed 出版商
von Saucken V, Jay T, Landreth G. The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's disease. Neurobiol Dis. 2020;145:105072 pubmed 出版商
Cignarella F, Filipello F, Bollman B, Cantoni C, Locca A, Mikesell R, et al. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta Neuropathol. 2020;140:513-534 pubmed 出版商
Cooper M, Pasini S, Lambert W, D Alessandro K, Yao V, Risner M, et al. Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress. Proc Natl Acad Sci U S A. 2020;117:18810-18821 pubmed 出版商
Lavoie Cardinal F, Bilodeau A, Lemieux M, Gardner M, Wiesner T, Laramée G, et al. Neuronal activity remodels the F-actin based submembrane lattice in dendrites but not axons of hippocampal neurons. Sci Rep. 2020;10:11960 pubmed 出版商
Fleuriet J, Willoughby C, Kueppers R, Mustari M, McLoon L. Eye alignment changes caused by sustained GDNF treatment of an extraocular muscle in infant non-human primates. Sci Rep. 2020;10:11927 pubmed 出版商
Berger S, Stattmann M, Cicvaric A, Monje F, Coiro P, Hotka M, et al. Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria. Acta Neuropathol Commun. 2020;8:38 pubmed 出版商
Cortese A, Tozza S, Yau W, Rossi S, Beecroft S, Jaunmuktane Z, et al. Cerebellar ataxia, neuropathy, vestibular areflexia syndrome due to RFC1 repeat expansion. Brain. 2020;143:480-490 pubmed 出版商
Ferrer I, Andrés Benito P, Zelaya M, Aguirre M, Carmona M, Ausín K, et al. Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy. Acta Neuropathol. 2020;139:735-771 pubmed 出版商
Moszczynski A, Harvey M, Fulcher N, de Oliveira C, McCunn P, Donison N, et al. Synergistic toxicity in an in vivo model of neurodegeneration through the co-expression of human TDP-43M337V and tauT175D protein. Acta Neuropathol Commun. 2019;7:170 pubmed 出版商
Wang S, Zhang Z, Almenar Queralt A, Leem J, DerMardirossian C, Roth D, et al. Caveolin-1 Phosphorylation Is Essential for Axonal Growth of Human Neurons Derived From iPSCs. Front Cell Neurosci. 2019;13:324 pubmed 出版商
Generous A, Harrison O, Troyanovsky R, Mateo M, Navaratnarajah C, Donohue R, et al. Trans-endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells. J Cell Sci. 2019;132: pubmed 出版商
McCanney G, Lindsay S, McGrath M, Willison H, Moss C, Bavington C, et al. The Use of Myelinating Cultures as a Screen of Glycomolecules for CNS Repair. Biology (Basel). 2019;8: pubmed 出版商
Miguel Hidalgo J, Carter K, Deloach P, Sanders L, Pang Y. Glucocorticoid-Induced Reductions of Myelination and Connexin 43 in Mixed Central Nervous System Cell Cultures Are Prevented by Mifepristone. Neuroscience. 2019;: pubmed 出版商
Stumpf S, Berghoff S, Trevisiol A, Spieth L, Düking T, Schneider L, et al. Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease. Acta Neuropathol. 2019;138:147-161 pubmed 出版商
Halabi E, Pinotsi D, Rivera Fuentes P. Photoregulated fluxional fluorophores for live-cell super-resolution microscopy with no apparent photobleaching. Nat Commun. 2019;10:1232 pubmed 出版商
Gomez Suaga P, Perez Nievas B, Glennon E, Lau D, Paillusson S, Mórotz G, et al. The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity. Acta Neuropathol Commun. 2019;7:35 pubmed 出版商
McWilliams I, Kielczewski J, Ireland D, Sykes J, Lewkowicz A, Konduru K, et al. Pseudovirus rVSVΔG-ZEBOV-GP Infects Neurons in Retina and CNS, Causing Apoptosis and Neurodegeneration in Neonatal Mice. Cell Rep. 2019;26:1718-1726.e4 pubmed 出版商
McCanney G, McGrath M, Otto T, Burchmore R, Yates E, Bavington C, et al. Low sulfated heparins target multiple proteins for central nervous system repair. Glia. 2019;67:668-687 pubmed 出版商
McGonigal R, Barrie J, Yao D, McLaughlin M, Cunningham M, Rowan E, et al. Glial Sulfatides and Neuronal Complex Gangliosides Are Functionally Interdependent in Maintaining Myelinating Axon Integrity. J Neurosci. 2019;39:63-77 pubmed 出版商
Wang X, Li R, Zacharek A, Landschoot Ward J, Wang F, Wu K, et al. Administration of Downstream ApoE Attenuates the Adverse Effect of Brain ABCA1 Deficiency on Stroke. Int J Mol Sci. 2018;19: pubmed 出版商
Iglesias J, Crampsie S, Strand C, Tachrount M, Thomas D, Holton J. Effect of Fluorinert on the Histological Properties of Formalin-Fixed Human Brain Tissue. J Neuropathol Exp Neurol. 2018;77:1085-1090 pubmed 出版商
Meehan G, McGonigal R, Cunningham M, Wang Y, Barrie J, Halstead S, et al. Differential binding patterns of anti-sulfatide antibodies to glial membranes. J Neuroimmunol. 2018;323:28-35 pubmed 出版商
Heuss N, Pierson M, Roehrich H, McPherson S, Gram A, Li L, et al. Optic nerve as a source of activated retinal microglia post-injury. Acta Neuropathol Commun. 2018;6:66 pubmed 出版商
Villalon E, Barry D, Byers N, Frizzi K, Jones M, Landayan D, et al. Internode length is reduced during myelination and remyelination by neurofilament medium phosphorylation in motor axons. Exp Neurol. 2018;306:158-168 pubmed 出版商
Yu G, Zheng S, Zhang H. Inhibition of myeloperoxidase by N-acetyl lysyltyrosylcysteine amide reduces experimental autoimmune encephalomyelitis-induced injury and promotes oligodendrocyte regeneration and neurogenesis in a murine model of progressive multiple sclerosis. Neuroreport. 2018;29:208-213 pubmed 出版商
Andrew R, Fernandez C, Stanley M, Jiang H, Nguyen P, Rice R, et al. Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2017;114:E9665-E9674 pubmed 出版商
Khedraki A, Reed E, Romer S, Wang Q, Romine W, Rich M, et al. Depressed Synaptic Transmission and Reduced Vesicle Release Sites in Huntington's Disease Neuromuscular Junctions. J Neurosci. 2017;37:8077-8091 pubmed 出版商
Cumberworth S, Barrie J, Cunningham M, de Figueiredo D, Schultz V, Wilder Smith A, et al. Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected. Acta Neuropathol Commun. 2017;5:50 pubmed 出版商
Mu L, Sobotka S, Chen J, Nyirenda T. Reinnervation of denervated muscle by implantation of nerve-muscle-endplate band graft to the native motor zone of the target muscle. Brain Behav. 2017;7:e00668 pubmed 出版商
van Nierop G, van Luijn M, Michels S, Melief M, Janssen M, Langerak A, et al. Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients. Acta Neuropathol. 2017;134:383-401 pubmed 出版商
Llorens F, Thüne K, Sikorska B, Schmitz M, Tahir W, Fernández Borges N, et al. Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease. Acta Neuropathol Commun. 2017;5:35 pubmed 出版商
Sama R, Fallini C, Gatto R, McKeon J, Song Y, Rotunno M, et al. ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation. Sci Rep. 2017;7:115 pubmed 出版商
Ling H, Morris H, Neal J, Lees A, Hardy J, Holton J, et al. Mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football (soccer) players. Acta Neuropathol. 2017;133:337-352 pubmed 出版商
Berghoff S, Gerndt N, Winchenbach J, Stumpf S, Hosang L, Odoardi F, et al. Dietary cholesterol promotes repair of demyelinated lesions in the adult brain. Nat Commun. 2017;8:14241 pubmed 出版商
Cui C, Ye X, Chopp M, Venkat P, Zacharek A, Yan T, et al. miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats. Stem Cells Transl Med. 2016;5:1656-1667 pubmed
Riku Y, Watanabe H, Yoshida M, Mimuro M, Iwasaki Y, Masuda M, et al. Marked Involvement of the Striatal Efferent System in TAR DNA-Binding Protein 43?kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis. J Neuropathol Exp Neurol. 2016;: pubmed
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Cui X, Chopp M, Zacharek A, Cui C, Yan T, Ning R, et al. D-4F Decreases White Matter Damage After Stroke in Mice. Stroke. 2016;47:214-20 pubmed 出版商
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McLean N, Popescu B, Gordon T, Zochodne D, Verge V. Delayed nerve stimulation promotes axon-protective neurofilament phosphorylation, accelerates immune cell clearance and enhances remyelination in vivo in focally demyelinated nerves. PLoS ONE. 2014;9:e110174 pubmed 出版商
Maire C, Ramkissoon S, Hayashi M, Haidar S, Ramkissoon L, diTomaso E, et al. Pten loss in Olig2 expressing neural progenitor cells and oligodendrocytes leads to interneuron dysplasia and leukodystrophy. Stem Cells. 2014;32:313-26 pubmed 出版商
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Kiryu Seo S, Ohno N, Kidd G, Komuro H, Trapp B. Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport. J Neurosci. 2010;30:6658-66 pubmed 出版商
Choi Y, Di Nardo A, Kramvis I, Meikle L, Kwiatkowski D, Sahin M, et al. Tuberous sclerosis complex proteins control axon formation. Genes Dev. 2008;22:2485-95 pubmed 出版商
Maurel P, Einheber S, Galinska J, Thaker P, Lam I, Rubin M, et al. Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination. J Cell Biol. 2007;178:861-74 pubmed
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产品信息
抗原 :
Neurofilament H
Apps. Abbrev. :
免疫组化-P, 西方墨点法, 免疫细胞化学
目录 :
801601
克隆 :
SMI 31
产品 :
Purified anti-Neurofilament H (NF-H), Phosphorylated
抗体亚型 :
Mouse IgG1, κ
其他名称 :
Neurofilament heavy polypeptide, NF-H, 200 kD neurofilament protein, neurofilament triplet H protein
规格 :
100微升
价格(美元) :
276美元
反应物种 :
人类, 小鼠, 大鼠
克隆性 :
单克隆
宿主 :
小鼠
共轭标签/标签/标记 :
PURE
应用注释 :
Additional reported applications (for the relevant formats) include: Western blotting 1 , immunohistochemistry 2,4 , and immunocytochemistry 4 . SMI 31 reacts with a phosphorylated epitope in extensively phosphorylated neurofilament H and, to a lesser extent, with neurofilament M in most mammalian species, which chicken and frog (Xenopus). Immunocytochemically, SMI 31 reacts broadly with thick and thin axons and some dendrites such as basket cell dendrites, but not Purkinje cell dendrites. Nerve cell bodies are generally unreactive. Other cells and tissues are unreactive except for peripheral axons. Phosphatase treatment of tissue sections or Western blots abolishes reaction with SMI 31. Staining is unaffected by trypsin. In pathological conditions, reaction with SMI 31 may be found also in neuronal cell bodies. Aberrant phosphorylation of neurofilament H in cell bodies can be demonstrated in neuronal cell cultures with SMI 31 by agents that induce stress-activated protein kinase. In its reaction with paired helical filaments in hereditary inclusion body myopathy, SMI 31 colocalizes with nitric oxide synthase, suggesting that oxidative stress may play a role in the pathogenic cascade of such degenerative diseases. SMI 31 co-immunoprecipitates neurofilament-associated kinase (NAK 115) via reaction of the antibody with the tail domain of neurofilament H.
更多信息或购买 :
公司信息
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。