出版应用/物种/样本/稀释 | 参考文献 |
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| Real R, Peter M, Trabalza A, Khan S, Smith M, Dopp J, et al. In vivo modeling of human neuron dynamics and Down syndrome. Science. 2018;362: pubmed 出版商
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| Reichenbach N, Delekate A, Breithausen B, Keppler K, Poll S, Schulte T, et al. P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model. J Exp Med. 2018;215:1649-1663 pubmed 出版商
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- proximity ligation assay; 大鼠; 图 5D
| Canu N, Pagano I, La Rosa L, Pellegrino M, Ciotti M, Mercanti D, et al. Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Front Mol Neurosci. 2017;10:15 pubmed 出版商
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| Porquet D, Andrés Benito P, Griñán Ferré C, Camins A, Ferrer I, Canudas A, et al. Amyloid and tau pathology of familial Alzheimer's disease APP/PS1 mouse model in a senescence phenotype background (SAMP8). Age (Dordr). 2015;37:9747 pubmed 出版商
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| Joshi G, Gan K, Johnson D, Johnson J. Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy. Neurobiol Aging. 2015;36:664-79 pubmed 出版商
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| Maarouf C, Kokjohn T, Walker D, Whiteside C, Kalback W, Whetzel A, et al. Biochemical assessment of precuneus and posterior cingulate gyrus in the context of brain aging and Alzheimer's disease. PLoS ONE. 2014;9:e105784 pubmed 出版商
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| Kang E, Kwon I, Koo J, Kim E, Kim C, Lee J, et al. Treadmill exercise represses neuronal cell death and inflammation during A?-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice. Apoptosis. 2013;18:1332-1347 pubmed 出版商
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| Reichenbach N, Delekate A, Plescher M, Schmitt F, Krauss S, Blank N, et al. Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model. EMBO Mol Med. 2019;11: pubmed 出版商
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| Hung C, Livesey F. Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease. Cell Rep. 2018;25:3647-3660.e2 pubmed 出版商
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| de Coninck D, Schmidt T, Schloetel J, Lang T. Packing Density of the Amyloid Precursor Protein in the Cell Membrane. Biophys J. 2018;114:1128-1141 pubmed 出版商
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| Miranda A, Lasiecka Z, Xu Y, Neufeld J, Shahriar S, Simoes S, et al. Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures. Nat Commun. 2018;9:291 pubmed 出版商
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| Jean Louis T, Rockwell P, Figueiredo Pereira M. Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by α- and β-secretases: relevance to Alzheimer's disease. Neurobiol Aging. 2018;62:130-145 pubmed 出版商
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| Williamson R, Laulagnier K, Miranda A, Fernandez M, Wolfe M, Sadoul R, et al. Disruption of amyloid precursor protein ubiquitination selectively increases amyloid ? (A?) 40 levels via presenilin 2-mediated cleavage. J Biol Chem. 2017;292:19873-19889 pubmed 出版商
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| García Ayllón M, Lopez Font I, Boix C, Fortea J, Sanchez Valle R, Lleo A, et al. C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease. Sci Rep. 2017;7:2477 pubmed 出版商
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| Paschkowsky S, Hamzé M, Oestereich F, Munter L. Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4. J Biol Chem. 2016;291:21903-21912 pubmed
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| Corbett G, Gonzalez F, Pahan K. Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP. Proc Natl Acad Sci U S A. 2015;112:8445-50 pubmed 出版商
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| Jiang Y, Mullaney K, Peterhoff C, Che S, Schmidt S, Boyer Boiteau A, et al. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci U S A. 2010;107:1630-5 pubmed 出版商
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