产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
Biotin (azide-free) anti-β-Amyloid, 1-16
目录 :
803007
规格 :
200微升
价格 :
654美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
生物素
克隆名称 :
6E10
反应物种 :
人类, 小鼠, fruit fly
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 35
出版应用/物种/样本/稀释参考文献
  • 酶联免疫吸附测定; 小鼠
Tournissac M, Vu T, Vrabic N, Hozer C, Tremblay C, Mélançon K, et al. Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model. Alzheimers Res Ther. 2021;13:103 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:2500; 图 4a
Latimer C, Burke B, Liachko N, Currey H, Kilgore M, Gibbons L, et al. Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathol Commun. 2019;7:9 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Hartl D, May P, Gu W, Mayhaus M, Pichler S, Spaniol C, et al. A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease. Mol Psychiatry. 2018;: pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Benvegnù S, Wahle T, Dotti C. E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion. Oncotarget. 2017;8:89439-89450 pubmed 出版商
  • 免疫印迹; fruit fly ; 1:10,000; 图 1
Bergkvist L, Sandin L, Kågedal K, Brorsson A. A?PP processing results in greater toxicity per amount of A?1-42 than individually expressed and secreted A?1-42 in Drosophila melanogaster. Biol Open. 2016;5:1030-9 pubmed 出版商
  • 免疫印迹; 人类
Webster S, Van Eldik L, Watterson D, Bachstetter A. Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment. J Neurosci. 2015;35:6554-69 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2500
Fowler S, Chiang A, Savjani R, Larson M, Sherman M, Schuler D, et al. Genetic modulation of soluble A? rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease. J Neurosci. 2014;34:7871-85 pubmed 出版商
Sompol P, Gollihue J, Kraner S, Artiushin I, Cloyd R, Chishti E, et al. Q134R: Small chemical compound with NFAT inhibitory properties improves behavioral performance and synapse function in mouse models of amyloid pathology. Aging Cell. 2021;20:e13416 pubmed 出版商
Chen J, Liu K, Hu B, Li R, Xin W, Chen H, et al. Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer's disease. Neuron. 2021;109:2292-2307.e5 pubmed 出版商
Metaxas A, Thygesen C, Briting S, Landau A, Darvesh S, Finsen B. Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer's Disease Patients. Front Cell Neurosci. 2019;13:538 pubmed 出版商
Duncan M, Farlow H, Tirumalaraju C, Yun D, Wang C, Howard J, et al. Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice. Alzheimers Dement (N Y). 2019;5:70-80 pubmed 出版商
Grant M, Handoko M, Rozga M, Brinkmalm G, Portelius E, Blennow K, et al. Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments. PLoS ONE. 2019;14:e0212815 pubmed 出版商
Busche M, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, et al. Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo. Nat Neurosci. 2019;22:57-64 pubmed 出版商
Thygesen C, Ilkjær L, Kempf S, Hemdrup A, von Linstow C, Babcock A, et al. Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease. Front Cell Neurosci. 2018;12:397 pubmed 出版商
Chernick D, Ortiz Valle S, Jeong A, Swaminathan S, Kandimalla K, Rebeck G, et al. High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia. J Neurochem. 2018;147:647-662 pubmed 出版商
Osborne C, West E, Bate C. The phospholipase A2 pathway controls a synaptic cholesterol ester cycle and synapse damage. J Cell Sci. 2018;131: pubmed 出版商
Chiang A, Fowler S, Reddy R, Pletnikova O, Troncoso J, Sherman M, et al. Discrete Pools of Oligomeric Amyloid-β Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis. Am J Pathol. 2018;188:739-756 pubmed 出版商
West E, Osborne C, Bate C. The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-?. J Cell Sci. 2017;130:3050-3059 pubmed 出版商
Mateus A, Gordon L, Wayne G, Almqvist H, Axelsson H, Seashore Ludlow B, et al. Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery. Proc Natl Acad Sci U S A. 2017;114:E6231-E6239 pubmed 出版商
Sompol P, Furman J, Pleiss M, Kraner S, Artiushin I, Batten S, et al. Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in A?-Bearing Mice. J Neurosci. 2017;37:6132-6148 pubmed 出版商
Zhou Z, Bachstetter A, Späni C, Roy S, Watterson D, Van Eldik L. Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes. J Neuroinflammation. 2017;14:75 pubmed 出版商
Saito S, Yamamoto Y, Maki T, Hattori Y, Ito H, Mizuno K, et al. Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy. Acta Neuropathol Commun. 2017;5:26 pubmed 出版商
Carter A, Letronne F, Fitz N, Mounier A, Wolfe C, Nam K, et al. Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice. PLoS ONE. 2017;12:e0172161 pubmed 出版商
Sherman M, LaCroix M, Amar F, Larson M, Forster C, Aguzzi A, et al. Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport. J Neurosci. 2016;36:9647-58 pubmed 出版商
Alfonso S, Callender J, Hooli B, Antal C, Mullin K, Sherman M, et al. Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease. Sci Signal. 2016;9:ra47 pubmed 出版商
Omata Y, Tharasegaran S, Lim Y, Yamasaki Y, Ishigaki Y, Tatsuno T, et al. Expression of amyloid-β in mouse cochlear hair cells causes an early-onset auditory defect in high-frequency sound perception. Aging (Albany NY). 2016;8:427-39 pubmed
Lathuilière A, Laversenne V, Astolfo A, Kopetzki E, Jacobsen H, Stampanoni M, et al. A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies. Brain. 2016;139:1587-604 pubmed 出版商
Forny Germano L, Lyra e Silva N, Batista A, Brito Moreira J, Gralle M, Boehnke S, et al. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci. 2014;34:13629-43 pubmed 出版商
Gowert N, Donner L, Chatterjee M, Eisele Y, Towhid S, Münzer P, et al. Blood platelets in the progression of Alzheimer's disease. PLoS ONE. 2014;9:e90523 pubmed 出版商
Larson M, Sherman M, Greimel S, Kuskowski M, Schneider J, Bennett D, et al. Soluble ?-synuclein is a novel modulator of Alzheimer's disease pathophysiology. J Neurosci. 2012;32:10253-66 pubmed 出版商
Zheng Y, Wang Q, Xiao B, Lu Q, Wang Y, Wang X. Involvement of receptor tyrosine kinase Tyro3 in amyloidogenic APP processing and ?-amyloid deposition in Alzheimer's disease models. PLoS ONE. 2012;7:e39035 pubmed 出版商
Abramowski D, Rabe S, Upadhaya A, Reichwald J, Danner S, Staab D, et al. Transgenic expression of intraneuronal A?42 but not A?40 leads to cellular A? lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology. J Neurosci. 2012;32:1273-83 pubmed 出版商
Thakker D, Weatherspoon M, Harrison J, Keene T, Lane D, KAEMMERER W, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci U S A. 2009;106:4501-6 pubmed 出版商
Oddo S, Caccamo A, Green K, Liang K, Tran L, Chen Y, et al. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2005;102:3046-51 pubmed
Herzig M, Winkler D, Burgermeister P, Pfeifer M, Kohler E, Schmidt S, et al. Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci. 2004;7:954-60 pubmed
产品信息
抗原 :
乙淀粉样蛋白1-16
Apps. Abbrev. :
免疫组化-P
目录 :
803007
克隆 :
6E10
产品 :
Biotin (azide-free) anti-β-Amyloid, 1-16
抗体亚型 :
Mouse IgG1, κ
其他名称 :
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
规格 :
200微升
价格(美元) :
654美元
反应物种 :
人类
克隆性 :
单克隆
宿主 :
小鼠
共轭标签/标签/标记 :
BIOTINAF
应用注释 :
This antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS). This antibody clone has been reported for use in immunohistochemistry of free-floating sections 2,13 .
更多信息或购买 :
公司信息
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。