产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
纯化抗髓鞘碱性蛋白质
目录 :
808402
规格 :
500微升
价格 :
499美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
SMI 99
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片
更多信息或购买 :
文章摘录数: 67
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 1:100; 图 6i
  • 免疫印迹; 小鼠; 图 6l
Xu J, Wen J, Fu L, Liao L, Zou Y, Zhang J, et al. Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral nerve injury in mice. J Neuroinflammation. 2021;18:234 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4a
Hoxha E, Balbo I, Parolisi R, Audano M, Montarolo F, Ravera F, et al. Elovl5 is required for proper action potential conduction along peripheral myelinated fibers. Glia. 2021;69:2419-2428 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 3c
Williams G, Marmion D, Schonhoff A, Jurkuvenaite A, Won W, Standaert D, et al. T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease. Acta Neuropathol. 2020;139:855-874 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 1d
Bonnefil V, Dietz K, Amatruda M, Wentling M, Aubry A, Dupree J, et al. Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 3a
Jeffries M, Urbanek K, Torres L, Wendell S, Rubio M, Fyffe Maricich S. ERK1/2 Activation in Preexisting Oligodendrocytes of Adult Mice Drives New Myelin Synthesis and Enhanced CNS Function. J Neurosci. 2016;36:9186-200 pubmed 出版商
  • 免疫组化; 小鼠; 图 1c
Safaiyan S, Kannaiyan N, Snaidero N, Brioschi S, Biber K, Yona S, et al. Age-related myelin degradation burdens the clearance function of microglia during aging. Nat Neurosci. 2016;19:995-8 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000; 图 6
Traka M, Podojil J, McCarthy D, Miller S, Popko B. Oligodendrocyte death results in immune-mediated CNS demyelination. Nat Neurosci. 2016;19:65-74 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:1000
Evonuk K, Baker B, Doyle R, Moseley C, Sestero C, Johnston B, et al. Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination. J Immunol. 2015;195:450-463 pubmed 出版商
  • 免疫印迹; 大鼠; 1:4000
Ronchi G, Haastert Talini K, Fornasari B, Perroteau I, Geuna S, Gambarotta G. The Neuregulin1/ErbB system is selectively regulated during peripheral nerve degeneration and regeneration. Eur J Neurosci. 2016;43:351-64 pubmed 出版商
  • 免疫组化-自由浮动切片; 大鼠
Way S, Podojil J, Clayton B, Zaremba A, Collins T, Kunjamma R, et al. Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic. Nat Commun. 2015;6:6532 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:1000; 图 4
  • 免疫印迹; 小鼠; 1:1000; 图 3
Pooya S, Liu X, Kumar V, Anderson J, Imai F, Zhang W, et al. The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism. Nat Commun. 2014;5:4993 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Lin Y, Pang X, Huang G, Jamison S, Fang J, Harding H, et al. Impaired eukaryotic translation initiation factor 2B activity specifically in oligodendrocytes reproduces the pathology of vanishing white matter disease in mice. J Neurosci. 2014;34:12182-91 pubmed 出版商
  • 免疫印迹; 犬
Boggs J, Homchaudhuri L, Ranagaraj G, Liu Y, Smith G, Harauz G. Interaction of myelin basic protein with cytoskeletal and signaling proteins in cultured primary oligodendrocytes and N19 oligodendroglial cells. BMC Res Notes. 2014;7:387 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000
Wahl S, McLane L, Bercury K, Macklin W, Wood T. Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination. J Neurosci. 2014;34:4453-65 pubmed 出版商
  • 免疫印迹; 小鼠
Washington P, Morffy N, Parsadanian M, Zapple D, Burns M. Experimental traumatic brain injury induces rapid aggregation and oligomerization of amyloid-beta in an Alzheimer's disease mouse model. J Neurotrauma. 2014;31:125-34 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
  • 免疫印迹; 小鼠; 1:1000
Liu J, Dietz K, Deloyht J, Pedre X, Kelkar D, Kaur J, et al. Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nat Neurosci. 2012;15:1621-3 pubmed 出版商
Benardais K, Ornelas I, Fauveau M, Brown T, Finseth L, Panic R, et al. p70S6 kinase regulates oligodendrocyte differentiation and is active in remyelinating lesions. Brain Commun. 2022;4:fcac025 pubmed 出版商
Radecki D, Samanta J. Isolation and culture of neural stem cells from adult mouse subventricular zone for genetic and pharmacological treatments with proliferation analysis. STAR Protoc. 2022;3:101153 pubmed 出版商
Ahn J, Lee H, Lee K, Lim J, Hwang J, Kim C, et al. Effects of Lipopolysaccharide on Oligodendrocyte Differentiation at Different Developmental Stages: an In Vitro Study. J Korean Med Sci. 2021;36:e332 pubmed 出版商
Liu R, Jia Y, Guo P, Jiang W, Bai R, Liu C. In Vivo Clonal Analysis Reveals Development Heterogeneity of Oligodendrocyte Precursor Cells Derived from Distinct Germinal Zones. Adv Sci (Weinh). 2021;8:e2102274 pubmed 出版商
Roth L, Akay Espinoza C, Grinspan J, Jordan Sciutto K. HIV-induced neuroinflammation inhibits oligodendrocyte maturation via glutamate-dependent activation of the PERK arm of the integrated stress response. Glia. 2021;69:2252-2271 pubmed 出版商
Huang S, Lu Q, Choi M, Zhang X, Kim J. Applying real-time monitoring of circadian oscillations in adult mouse brain slices to study communications between brain regions. STAR Protoc. 2021;2:100416 pubmed 出版商
Alam M, Zhao X, Liao Y, Mathur R, McCallum S, Mazurkiewicz J, et al. Deficiency of Microglial Autophagy Increases the Density of Oligodendrocytes and Susceptibility to Severe Forms of Seizures. Eneuro. 2021;8: pubmed 出版商
Zhang S, Wang Y, Zhu X, Song L, Zhan X, Ma E, et al. The Wnt Effector TCF7l2 Promotes Oligodendroglial Differentiation by Repressing Autocrine BMP4-Mediated Signaling. J Neurosci. 2021;41:1650-1664 pubmed 出版商
Choi K, Lee J, Kang H. Myelination defects in the medial prefrontal cortex of Fkbp5 knockout mice. FASEB J. 2021;35:e21297 pubmed 出版商
Zhang S, Wang Y, Xu J, Kim B, Deng W, Guo F. HIFα Regulates Developmental Myelination Independent of Autocrine Wnt Signaling. J Neurosci. 2021;41:251-268 pubmed 出版商
Keogh C, Kim D, Pusceddu M, Knotts T, Rabasa G, Sladek J, et al. Myelin as a regulator of development of the microbiota-gut-brain axis. Brain Behav Immun. 2021;91:437-450 pubmed 出版商
Allan K, Hu L, Scavuzzo M, Morton A, Gevorgyan A, Cohn E, et al. Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function. Cell Stem Cell. 2021;28:257-272.e11 pubmed 出版商
Huang S, Choi M, Huang H, Wang X, Chang Y, Kim J. Demyelination Regulates the Circadian Transcription Factor BMAL1 to Signal Adult Neural Stem Cells to Initiate Oligodendrogenesis. Cell Rep. 2020;33:108394 pubmed 出版商
Ma Q, Matsunaga A, Ho B, Oksenberg J, Didonna A. Oligodendrocyte-specific Argonaute profiling identifies microRNAs associated with experimental autoimmune encephalomyelitis. J Neuroinflammation. 2020;17:297 pubmed 出版商
Reed C, Frick L, Weaver A, Sidoli M, Schlant E, Feltri M, et al. Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury. J Neurosci. 2020;40:6165-6176 pubmed 出版商
Elitt M, Barbar L, Shick H, Powers B, Maeno Hikichi Y, Madhavan M, et al. Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease. Nature. 2020;585:397-403 pubmed 出版商
Orthmann Murphy J, Call C, Molina Castro G, Hsieh Y, Rasband M, Calabresi P, et al. Remyelination alters the pattern of myelin in the cerebral cortex. elife. 2020;9: pubmed 出版商
Wang Q, Ding S, Li Y, Royall J, Feng D, Lesnar P, et al. The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas. Cell. 2020;181:936-953.e20 pubmed 出版商
Hanf K, Arndt J, Liu Y, Gong B, Rushe M, Sopko R, et al. Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site. MAbs. 2020;12:1713648 pubmed 出版商
Zhang Y, Kang H, Han K. Differential cell-type-expression of CYFIP1 and CYFIP2 in the adult mouse hippocampus. Anim Cells Syst (Seoul). 2019;23:380-383 pubmed 出版商
Chew L, Ming X, McEllin B, Dupree J, Hong E, Catron M, et al. Sox17 Regulates a Program of Oligodendrocyte Progenitor Cell Expansion and Differentiation during Development and Repair. Cell Rep. 2019;29:3173-3186.e7 pubmed 出版商
Gail Canter R, Huang W, Choi H, Wang J, Ashley Watson L, Yao C, et al. 3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice. Commun Biol. 2019;2:360 pubmed 出版商
Sophie B, Jacob H, Jordan V, Yungki P, Laura F, Yannick P. YAP and TAZ Regulate Cc2d1b and Purβ in Schwann Cells. Front Mol Neurosci. 2019;12:177 pubmed 出版商
Xin W, Mironova Y, Shen H, Marino R, Waisman A, Lamers W, et al. Oligodendrocytes Support Neuronal Glutamatergic Transmission via Expression of Glutamine Synthetase. Cell Rep. 2019;27:2262-2271.e5 pubmed 出版商
Ou Z, Ma Y, Sun Y, Zheng G, Wang S, Xing R, et al. A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism. Cell Rep. 2019;26:2984-2997.e4 pubmed 出版商
Tammia M, Mi R, Sluch V, Zhu A, Chung T, Shinn D, et al. Egr2 overexpression in Schwann cells increases myelination frequency in vitro. Heliyon. 2018;4:e00982 pubmed 出版商
Rumajogee P, Altamentova S, Li L, Li J, Wang J, Kuurstra A, et al. Exogenous Neural Precursor Cell Transplantation Results in Structural and Functional Recovery in a Hypoxic-Ischemic Hemiplegic Mouse Model. Eneuro. 2018;5: pubmed 出版商
de Rosa V, Secondo A, Pannaccione A, Ciccone R, Formisano L, Guida N, et al. D-Aspartate treatment attenuates myelin damage and stimulates myelin repair. EMBO Mol Med. 2019;11: pubmed 出版商
Zhao Y, Sun X, Qi X. Inhibition of Drp1 hyperactivation reduces neuropathology and behavioral deficits in zQ175 knock-in mouse model of Huntington's disease. Biochem Biophys Res Commun. 2018;507:319-323 pubmed 出版商
Žunić Išasegi I, Rados M, Krsnik Z, Rados M, Benjak V, Kostovic I. Interactive histogenesis of axonal strata and proliferative zones in the human fetal cerebral wall. Brain Struct Funct. 2018;223:3919-3943 pubmed 出版商
Swartzlander D, Propson N, Roy E, Saito T, Saido T, Wang B, et al. Concurrent cell type-specific isolation and profiling of mouse brains in inflammation and Alzheimer's disease. JCI Insight. 2018;3: pubmed 出版商
Yermakov L, Drouet D, GRIGGS R, Elased K, Susuki K. Type 2 Diabetes Leads to Axon Initial Segment Shortening in db/db Mice. Front Cell Neurosci. 2018;12:146 pubmed 出版商
Susuki K, Zollinger D, Chang K, Zhang C, Huang C, Tsai C, et al. Glial βII Spectrin Contributes to Paranode Formation and Maintenance. J Neurosci. 2018;38:6063-6075 pubmed 出版商
Luo F, Zhang J, Burke K, Romito Digiacomo R, Miller R, Yang Y. Oligodendrocyte-specific loss of Cdk5 disrupts the architecture of nodes of Ranvier as well as learning and memory. Exp Neurol. 2018;306:92-104 pubmed 出版商
Larson V, Mironova Y, Vanderpool K, Waisman A, Rash J, Agarwal A, et al. Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility. elife. 2018;7: pubmed 出版商
González Fernández E, Jeong H, Fukaya M, Kim H, Khawaja R, Srivastava I, et al. PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling. elife. 2018;7: pubmed 出版商
Barron T, Saifetiarova J, Bhat M, Kim J. Myelination of Purkinje axons is critical for resilient synaptic transmission in the deep cerebellar nucleus. Sci Rep. 2018;8:1022 pubmed 出版商
McLane L, Bourne J, Evangelou A, Khandker L, Macklin W, Wood T. Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination. J Neurosci. 2017;37:7534-7546 pubmed 出版商
Bermejo P, Lopez M, Larraya I, Chamorro J, Cobo J, Ordonez S, et al. Innervation of the Human Cavum Conchae and Auditory Canal: Anatomical Basis for Transcutaneous Auricular Nerve Stimulation. Biomed Res Int. 2017;2017:7830919 pubmed 出版商
Pamies D, Barreras P, Block K, Makri G, Kumar A, Wiersma D, et al. A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity. ALTEX. 2017;34:362-376 pubmed 出版商
Shi Y, Shu J, Liang Z, Yuan S, Tang S. EXPRESS: Oligodendrocytes in HIV-associated pain pathogenesis. Mol Pain. 2016;12: pubmed 出版商
Battefeld A, Klooster J, Kole M. Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity. Nat Commun. 2016;7:11298 pubmed 出版商
Luo F, Zhang J, Burke K, Miller R, Yang Y. The Activators of Cyclin-Dependent Kinase 5 p35 and p39 Are Essential for Oligodendrocyte Maturation, Process Formation, and Myelination. J Neurosci. 2016;36:3024-37 pubmed 出版商
Liu J, Dupree J, Gacias M, Frawley R, Sikder T, Naik P, et al. Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice. J Neurosci. 2016;36:957-62 pubmed 出版商
Hernandez M, Patzig J, Mayoral S, Costa K, Chan J, CASACCIA P. Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes. J Neurosci. 2016;36:806-13 pubmed 出版商
Fyffe Maricich S, Karlo J, Landreth G, Miller R. The ERK2 mitogen-activated protein kinase regulates the timing of oligodendrocyte differentiation. J Neurosci. 2011;31:843-50 pubmed 出版商
Kiryu Seo S, Ohno N, Kidd G, Komuro H, Trapp B. Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport. J Neurosci. 2010;30:6658-66 pubmed 出版商
Del Valle L, Pina Oviedo S, Perez Liz G, Augelli B, Azizi S, Khalili K, et al. Bone marrow-derived mesenchymal stem cells undergo JCV T-antigen mediated transformation and generate tumors with neuroectodermal characteristics. Cancer Biol Ther. 2010;9:286-94 pubmed 出版商
Samanta J, Alden T, Gobeske K, Kan L, Kessler J. Noggin protects against ischemic brain injury in rodents. Stroke. 2010;41:357-62 pubmed 出版商
Werner H, Kuhlmann K, Shen S, Uecker M, Schardt A, Dimova K, et al. Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J Neurosci. 2007;27:7717-30 pubmed
Park S, Miller R, Krane I, Vartanian T. The erbB2 gene is required for the development of terminally differentiated spinal cord oligodendrocytes. J Cell Biol. 2001;154:1245-58 pubmed
产品信息
抗原 :
髓鞘碱性蛋白质
Apps. Abbrev. :
免疫组化-P, 西方墨点法, 免疫细胞化学
目录 :
808402
克隆 :
SMI 99
产品 :
纯化抗髓鞘碱性蛋白质
抗体亚型 :
Mouse IgG2b, κ
其他名称 :
MBP, Golli-MBP, myelin A1 protein, myelin membrane encephalitogenic protein
规格 :
500微升
价格(美元) :
499美元
反应物种 :
人类, 小鼠, 大鼠
克隆性 :
单克隆
宿主 :
小鼠
共轭标签/标签/标记 :
PURE
应用注释 :
This antibody reacts with the sequence Ala-Ser-Asp-Tyr-Lys-Ser in position 131-136 of the classic human myelin basic protein. The antibody detects myelin basic protein from most mammalian species. This antibody detects developing and adult myelin, developing oligodedrocytes and distinguishes oligodendrocytes from astrocytes, microglia, neurons, and other cells in brain sections. The combination of this antibody with clone SMI-91 and/or SMI-94 is useful for immunocytochemical studies on the progression of normal and pathologic myelination.
更多信息或购买 :
公司信息
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。