产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
Purified (azide-free) anti-α-Synuclein
目录 :
824301
规格 :
100微升
价格 :
234美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
Syn303
反应物种 :
人类
应用 :
免疫印迹, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 19
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 1a
Zunke F, Moise A, Belur N, Gelyana E, Stojkovska I, Dzaferbegovic H, et al. Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide. Neuron. 2018;97:92-107.e10 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1e
Mazzulli J, Zunke F, Tsunemi T, Toker N, Jeon S, Burbulla L, et al. Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons. J Neurosci. 2016;36:7693-706 pubmed 出版商
Klingstedt T, Ghetti B, Holton J, Ling H, Nilsson K, Goedert M. Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson's disease and multiple system atrophy. Acta Neuropathol Commun. 2019;7:193 pubmed 出版商
Abd Elhadi S, Grigoletto J, Poli M, Arosio P, Arkadir D, Sharon R. α-Synuclein in blood cells differentiates Parkinson's disease from healthy controls. Ann Clin Transl Neurol. 2019;6:2426-2436 pubmed 出版商
Cuddy L, Wani W, Morella M, Pitcairn C, Tsutsumi K, Fredriksen K, et al. Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein. Neuron. 2019;104:869-884.e11 pubmed 出版商
Nicot S, Verchère J, Belondrade M, Mayran C, Betemps D, Bougard D, et al. Seeded propagation of α-synuclein aggregation in mouse brain using protein misfolding cyclic amplification. FASEB J. 2019;33:12073-12086 pubmed 出版商
Li X, Koudstaal W, Fletcher L, Costa M, Van Winsen M, Siregar B, et al. Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology. Acta Neuropathol. 2019;137:825-836 pubmed 出版商
Sargent D, Verchère J, Lazizzera C, Gaillard D, Lakhdar L, Streichenberger N, et al. 'Prion-like' propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum. J Neurochem. 2017;143:126-135 pubmed 出版商
Covell D, Robinson J, Akhtar R, Grossman M, Weintraub D, Bucklin H, et al. Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease. Neuropathol Appl Neurobiol. 2017;43:604-620 pubmed 出版商
Tran H, Chung C, Iba M, Zhang B, Trojanowski J, Luk K, et al. ?-synuclein immunotherapy blocks uptake and templated propagation of misfolded ?-synuclein and neurodegeneration. Cell Rep. 2014;7:2054-65 pubmed 出版商
Colla E, Jensen P, Pletnikova O, Troncoso J, Glabe C, Lee M. Accumulation of toxic ?-synuclein oligomer within endoplasmic reticulum occurs in ?-synucleinopathy in vivo. J Neurosci. 2012;32:3301-5 pubmed 出版商
Tsika E, Moysidou M, Guo J, Cushman M, Gannon P, Sandaltzopoulos R, et al. Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration. J Neurosci. 2010;30:3409-18 pubmed 出版商
Luk K, Song C, O BRIEN P, Stieber A, Branch J, Brunden K, et al. Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proc Natl Acad Sci U S A. 2009;106:20051-6 pubmed 出版商
Soper J, Roy S, Stieber A, Lee E, Wilson R, Trojanowski J, et al. Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae. Mol Biol Cell. 2008;19:1093-103 pubmed 出版商
Fan Y, Limprasert P, Murray I, Smith A, Lee V, Trojanowski J, et al. Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression. Hum Mol Genet. 2006;15:3002-11 pubmed
Wilson C, Murphy D, Giasson B, Zhang B, Trojanowski J, Lee V. Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons. J Cell Biol. 2004;165:335-46 pubmed
Uryu K, Giasson B, Longhi L, Martinez D, Murray I, Conte V, et al. Age-dependent synuclein pathology following traumatic brain injury in mice. Exp Neurol. 2003;184:214-24 pubmed
Neumann M, Kahle P, Giasson B, Ozmen L, Borroni E, Spooren W, et al. Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. J Clin Invest. 2002;110:1429-39 pubmed
Giasson B, Duda J, Quinn S, Zhang B, Trojanowski J, Lee V. Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron. 2002;34:521-33 pubmed
产品信息
抗原 :
alpha突触核蛋白
Apps. Abbrev. :
免疫组化-P
目录 :
824301
克隆 :
Syn303
产品 :
Purified (azide-free) anti-α-Synuclein
抗体亚型 :
小鼠IgG1
其他名称 :
Alpha-synuclein, synuclein alpha-140, NACP, PARK1, PARK4, PD1
规格 :
100微升
价格(美元) :
234美元
反应物种 :
人类
克隆性 :
单克隆
宿主 :
小鼠
共轭标签/标签/标记 :
PUREAF
应用注释 :
This antibody is effective in formalin-fixed paraffin-embedded immunohistochemical staining (IHC-P).
更多信息或购买 :
公司信息
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。