产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
Purified anti-α-Synuclein Phospho (Ser129)
目录 :
825701
规格 :
100微升
价格 :
335美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
P同义词/81A
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 27
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:2000
Zhang C, Zhao M, Wang B, Su Z, Guo B, Qin L, et al. The Nrf2-NLRP3-caspase-1 axis mediates the neuroprotective effects of Celastrol in Parkinson's disease. Redox Biol. 2021;47:102134 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:5000; 图 1c
Bieri G, Brahic M, Bousset L, Couthouis J, Kramer N, Ma R, et al. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons. Acta Neuropathol. 2019;137:961-980 pubmed 出版商
  • 免疫组化; 小鼠; 1:10,000; 图 2b
Hu D, Sun X, Liao X, Zhang X, Zarabi S, Schimmer A, et al. Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathol. 2019;137:939-960 pubmed 出版商
Cai W, Srivastava P, Feng D, Lin Y, Vanderburg C, Xu Y, et al. Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease. Mol Neurodegener. 2022;17:16 pubmed 出版商
Yan M, Xiong M, Dai L, Zhang X, Zha Y, Deng X, et al. Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson's disease. NPJ Parkinsons Dis. 2022;8:1 pubmed 出版商
Stykel M, Humphries K, Kamski Hennekam E, Buchner Duby B, Porte Trachsel N, Ryan T, et al. α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology. Cell Rep. 2021;35:109099 pubmed 出版商
Kim H, Shin J, Lee Y, Yun S, Maeng H, Lee Y. Brain Endothelial P-Glycoprotein Level Is Reduced in Parkinson's Disease via a Vitamin D Receptor-Dependent Pathway. Int J Mol Sci. 2020;21: pubmed 出版商
Stoyka L, Arrant A, Thrasher D, Russell D, Freire J, Mahoney C, et al. Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded α-synuclein inclusions. Neurobiol Dis. 2020;134:104708 pubmed 出版商
Park H, Choi D, Park J, Sim C, Park S, Kang S, et al. Scalable and Isotropic Expansion of Tissues with Simply Tunable Expansion Ratio. Adv Sci (Weinh). 2019;6:1901673 pubmed 出版商
Ham S, Kim H, Yoon J, Kim H, Song B, Choi J, et al. Therapeutic Evaluation of Synthetic Peucedanocoumarin III in an Animal Model of Parkinson's Disease. Int J Mol Sci. 2019;20: pubmed 出版商
Cuddy L, Wani W, Morella M, Pitcairn C, Tsutsumi K, Fredriksen K, et al. Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein. Neuron. 2019;104:869-884.e11 pubmed 出版商
Schaser A, Osterberg V, Dent S, Stackhouse T, Wakeham C, Boutros S, et al. Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders. Sci Rep. 2019;9:10919 pubmed 出版商
Yamasaki T, Holmes B, Furman J, Dhavale D, Su B, Song E, et al. Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics. J Biol Chem. 2019;294:1045-1058 pubmed 出版商
Ishiki A, Harada R, Kai H, Sato N, Totsune T, Tomita N, et al. Neuroimaging-pathological correlations of [18F]THK5351 PET in progressive supranuclear palsy. Acta Neuropathol Commun. 2018;6:53 pubmed 出版商
Ryan T, Bamm V, Stykel M, Coackley C, Humphries K, Jamieson Williams R, et al. Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. Nat Commun. 2018;9:817 pubmed 出版商
Cai W, Feng D, Schwarzschild M, McLean P, Chen X. Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice. EBioMedicine. 2018;29:13-22 pubmed 出版商
Groveman B, Orru C, Hughson A, Raymond L, Zanusso G, Ghetti B, et al. Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC. Acta Neuropathol Commun. 2018;6:7 pubmed 出版商
Bottani E, Cerutti R, Harbour M, Ravaglia S, Doğan S, Giordano C, et al. TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis of Mitochondrial Respiratory Complex III. Mol Cell. 2017;67:96-105.e4 pubmed 出版商
Covell D, Robinson J, Akhtar R, Grossman M, Weintraub D, Bucklin H, et al. Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease. Neuropathol Appl Neurobiol. 2017;43:604-620 pubmed 出版商
Doppler K, Jentschke H, Schulmeyer L, Vadász D, Janzen A, Luster M, et al. Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease. Acta Neuropathol. 2017;133:535-545 pubmed 出版商
Ip C, Klaus L, Karikari A, Visanji N, Brotchie J, Lang A, et al. AAV1/2-induced overexpression of A53T-?-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease. Acta Neuropathol Commun. 2017;5:11 pubmed 出版商
Lee J, Derkinderen P, Kordower J, Freeman R, Munoz D, Kremer T, et al. The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease. J Neuropathol Exp Neurol. 2017;76:2-15 pubmed 出版商
Adamowicz D, Roy S, Salmon D, Galasko D, Hansen L, Masliah E, et al. Hippocampal ?-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology. J Neurosci. 2017;37:1675-1684 pubmed 出版商
Sampson T, Debelius J, Thron T, Janssen S, Shastri G, Ilhan Z, et al. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease. Cell. 2016;167:1469-1480.e12 pubmed 出版商
Breid S, Bernis M, Babila J, Garza M, Wille H, TAMGUNEY G. Neuroinvasion of ?-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation. J Virol. 2016;90:9182-93 pubmed 出版商
Doppler K, Volkmann J, Sommer C. Skin biopsies in the differential diagnosis of parkinsonism: are we ready for simplified protocols?. Brain. 2016;139:e5 pubmed 出版商
Volpicelli Daley L, Luk K, Lee V. Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates. Nat Protoc. 2014;9:2135-46 pubmed 出版商
产品信息
抗原 :
alpha突触核蛋白磷酸化Ser129
Apps. Abbrev. :
免疫组化-P, 免疫细胞化学, 免疫组化-F, 西方墨点法
目录 :
825701
克隆 :
P同义词/81A
产品 :
Purified anti-α-Synuclein Phospho (Ser129)
抗体亚型 :
Mouse IgG2a, κ
其他名称 :
Synuclein alpha-140, non-A4 component of amyloid, alpha-synuclein, isoform NACP140, non-A beta component of AD amyloid Parkinson disease (autosomal dominant, Lewy body) 4
规格 :
100微升
价格(美元) :
335美元
反应物种 :
人类
克隆性 :
单克隆
宿主 :
小鼠
共轭标签/标签/标记 :
PURE
免疫原 :
This monoclonal antibody was raised against a synthetic peptide corresponding to amino acids 124 - 134 of α-synuclein, phosphorylated at Serine 129, and conjugated to KLH via a C-terminal Cysteine.
应用注释 :
This antibody is effective in immunohistochemistry (IHC-P). Additional reported applications (for the relevant formats) include: Western blotting, immunohistochemisty on frozen tissue sections (IHC-F), and immunocytochemistry. P-syn/81A is a mAb that is specific to alpha synuclein that has been phosphorylated on serine 129.
更多信息或购买 :
公司信息
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。