产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
纯化角蛋白8单克隆抗体
目录 :
904801
规格 :
250微升
价格 :
374美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
1E8
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 47
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 图 5e
Wang H, Xiang D, Liu B, He A, Randle H, Zhang K, et al. Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer. Cell. 2019;178:135-151.e19 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 2f
Chiche A, Di Cicco A, Sesma Sanz L, Bresson L, de la Grange P, Glukhova M, et al. p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling. Breast Cancer Res. 2019;21:13 pubmed 出版商
  • 免疫组化; 小鼠; 图 s6a
Barros Silva J, Linn D, Steiner I, Guo G, Ali A, Pakula H, et al. Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer. Cell Rep. 2018;25:3504-3518.e6 pubmed 出版商
  • 免疫组化; 人类; 1:1000; 图 2g
Poli V, Fagnocchi L, Fasciani A, Cherubini A, Mazzoleni S, Ferrillo S, et al. MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state. Nat Commun. 2018;9:1024 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 3b
Keckesova Z, Donaher J, De Cock J, Freinkman E, Lingrell S, Bachovchin D, et al. LACTB is a tumour suppressor that modulates lipid metabolism and cell state. Nature. 2017;543:681-686 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 s1h
Lu X, Horner J, Paul E, Shang X, Troncoso P, Deng P, et al. Effective combinatorial immunotherapy for castration-resistant prostate cancer. Nature. 2017;543:728-732 pubmed 出版商
  • 免疫组化; 小鼠; 图 4c
Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, et al. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest. 2017;127:1284-1302 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 4b
Tao L, Xiang D, Xie Y, Bronson R, Li Z. Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours. Nat Commun. 2017;8:14431 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Chiche A, Moumen M, Romagnoli M, Petit V, Lasla H, Jézéquel P, et al. p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors. Oncogene. 2017;36:2355-2365 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:1000; 图 3c
Su Q, Zhang B, Zhang L, Dang T, Rowley D, Ittmann M, et al. Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer. Oncogene. 2017;36:618-627 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 s1
  • 免疫印迹; 人类; 1:1000; 图 2b
Dutta A, Le Magnen C, Mitrofanova A, Ouyang X, Califano A, Abate Shen C. Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation. Science. 2016;352:1576-80 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 2
Wang N, Dong B, Quan Y, Chen Q, Chu M, Xu J, et al. Regulation of Prostate Development and Benign Prostatic Hyperplasia by Autocrine Cholinergic Signaling via Maintaining the Epithelial Progenitor Cells in Proliferating Status. Stem Cell Reports. 2016;6:668-678 pubmed 出版商
  • 免疫细胞化学; 人类; 1:300; 图 2b
Haikala H, Klefström J, Eilers M, Wiese K. MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures. Cell Cycle. 2016;15:316-23 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:1000; 图 1
Johnson D, Hooker E, Luong R, Yu E, He Y, Gonzalgo M, et al. Conditional Expression of the Androgen Receptor Increases Susceptibility of Bladder Cancer in Mice. PLoS ONE. 2016;11:e0148851 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 7
Wang Z, Kim J, Teng Y, Ding H, Zhang J, Hai T, et al. Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5(+)CK8(+) epithelial cells. Oncogene. 2016;35:3555-64 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 2
  • 免疫细胞化学; 人类; 1:100; 图 4
Abou Kheir W, Eid A, El Merahbi R, Assaf R, Daoud G. A Unique Expression of Keratin 14 in a Subset of Trophoblast Cells. PLoS ONE. 2015;10:e0139939 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:2500; 图 1
Lee S, Johnson D, Luong R, Yu E, Cunha G, Nusse R, et al. Wnt/β-Catenin-Responsive Cells in Prostatic Development and Regeneration. Stem Cells. 2015;33:3356-67 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:50; 图 2
Lokody I, Francis J, Gardiner J, Erler J, Swain A. Pten Regulates Epithelial Cytodifferentiation during Prostate Development. PLoS ONE. 2015;10:e0129470 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 s2
Ruscetti M, Quach B, Dadashian E, Mulholland D, Wu H. Tracking and Functional Characterization of Epithelial-Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis. Cancer Res. 2015;75:2749-59 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:1000
Wang B, Wang X, Long J, Eastham Anderson J, Firestein R, Junttila M. Castration-resistant Lgr5(+) cells are long-lived stem cells required for prostatic regeneration. Stem Cell Reports. 2015;4:768-79 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:800; 图 4
Lee S, Luong R, Johnson D, Cunha G, Rivina L, Gonzalgo M, et al. Androgen signaling is a confounding factor for β-catenin-mediated prostate tumorigenesis. Oncogene. 2016;35:702-14 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Sicoli D, Jiao X, Ju X, Velasco Velázquez M, Ertel A, Addya S, et al. CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines. Cancer Res. 2014;74:7103-14 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Easter S, Mitchell E, Baxley S, Desmond R, Frost A, Serra R. Wnt5a suppresses tumor formation and redirects tumor phenotype in MMTV-Wnt1 tumors. PLoS ONE. 2014;9:e113247 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Sackmann Sala L, Chiche A, Mosquera Garrote N, Boutillon F, Cordier C, Pourmir I, et al. Prolactin-induced prostate tumorigenesis links sustained Stat5 signaling with the amplification of basal/stem cells and emergence of putative luminal progenitors. Am J Pathol. 2014;184:3105-19 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 3
Zhang C, Guo Y, Cui J, Zhu H, Gao W. Cytokeratin 18 is not required for morphogenesis of developing prostates but contributes to adult prostate regeneration. Biomed Res Int. 2013;2013:576472 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200
Lafkas D, Rodilla V, Huyghe M, Mourao L, Kiaris H, Fre S. Notch3 marks clonogenic mammary luminal progenitor cells in vivo. J Cell Biol. 2013;203:47-56 pubmed 出版商
Sfakianos J, Daza J, Hu Y, Anastos H, Bryant G, Bareja R, et al. Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers. Nat Commun. 2020;11:2540 pubmed 出版商
Sumbal J, Chiche A, Charifou E, Koledova Z, Li H. Primary Mammary Organoid Model of Lactation and Involution. Front Cell Dev Biol. 2020;8:68 pubmed 出版商
Florian S, Iwamoto Y, Coughlin M, Weissleder R, Mitchison T. A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor. Proc Natl Acad Sci U S A. 2019;116:11444-11453 pubmed 出版商
Kwon O, Zhang Y, Li Y, Wei X, Zhang L, Chen R, et al. Functional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single-Cell RNA-Seq. iScience. 2019;13:328-338 pubmed 出版商
Lee D, Yu E, Aldahl J, Yang J, He Y, Hooker E, et al. Deletion of the p16INK4a tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate. PLoS ONE. 2019;14:e0211153 pubmed 出版商
Jiao X, Li Z, Wang M, Katiyar S, Di Sante G, Farshchian M, et al. Dachshund Depletion Disrupts Mammary Gland Development and Diverts the Composition of the Mammary Gland Progenitor Pool. Stem Cell Reports. 2019;12:135-151 pubmed 出版商
Xiong X, Schober M, Tassone E, Khodadadi Jamayran A, Sastre Perona A, Zhou H, et al. KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer. Cell Rep. 2018;25:3006-3020.e7 pubmed 出版商
Mi J, Hooker E, Balog S, Zeng H, Johnson D, He Y, et al. Activation of hepatocyte growth factor/MET signaling initiates oncogenic transformation and enhances tumor aggressiveness in the murine prostate. J Biol Chem. 2018;293:20123-20136 pubmed 出版商
Livshits G, Alonso Curbelo D, Morris J, Koche R, Saborowski M, Wilkinson J, et al. Arid1a restrains Kras-dependent changes in acinar cell identity. elife. 2018;7: pubmed 出版商
Li Q, Alsaidan O, Ma Y, Kim S, Liu J, Albers T, et al. Pharmacologically targeting the myristoylation of the scaffold protein FRS2α inhibits FGF/FGFR-mediated oncogenic signaling and tumor progression. J Biol Chem. 2018;293:6434-6448 pubmed 出版商
He Y, Hooker E, Yu E, Wu H, Cunha G, Sun Z. An Indispensable Role of Androgen Receptor in Wnt Responsive Cells During Prostate Development, Maturation, and Regeneration. Stem Cells. 2018;36:891-902 pubmed 出版商
Li Q, Ingram L, Kim S, Beharry Z, Cooper J, Cai H. Paracrine Fibroblast Growth Factor Initiates Oncogenic Synergy with Epithelial FGFR/Src Transformation in Prostate Tumor Progression. Neoplasia. 2018;20:233-243 pubmed 出版商
Bresson L, Faraldo M, Di Cicco A, Quintanilla M, Glukhova M, Deugnier M. Podoplanin regulates mammary stem cell function and tumorigenesis by potentiating Wnt/β-catenin signaling. Development. 2018;145: pubmed 出版商
Yang C, Melhuish T, Spencer A, Ni L, Hao Y, Jividen K, et al. The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression. Prostate. 2017;77:1452-1467 pubmed 出版商
Ai J, Tai P, Lu Y, Li J, Ma H, Su Q, et al. Characterization of adenoviral transduction profile in prostate cancer cells and normal prostate tissue. Prostate. 2017;77:1265-1270 pubmed 出版商
Wu M, Ingram L, Tolosa E, Vera R, Li Q, Kim S, et al. Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis. J Biol Chem. 2016;291:25749-25760 pubmed
Gao D, Zhan Y, Di W, Moore A, Sher J, Guan Y, et al. A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon. PLoS ONE. 2016;11:e0161084 pubmed 出版商
Kwon O, Zhang B, Zhang L, Xin L. High fat diet promotes prostatic basal-to-luminal differentiation and accelerates initiation of prostate epithelial hyperplasia originated from basal cells. Stem Cell Res. 2016;16:682-91 pubmed 出版商
Park J, Lee J, Phillips J, Huang P, Cheng D, Huang J, et al. Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay. Proc Natl Acad Sci U S A. 2016;113:4482-7 pubmed 出版商
Linn D, Penney K, Bronson R, Mucci L, Li Z. Deletion of Interstitial Genes between TMPRSS2 and ERG Promotes Prostate Cancer Progression. Cancer Res. 2016;76:1869-81 pubmed 出版商
Hübner A, Mulholland D, Standen C, Karasarides M, Cavanagh Kyros J, Barrett T, et al. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A. 2012;109:12046-51 pubmed 出版商
产品信息
抗原 :
角蛋白8
Apps. Abbrev. :
免疫组化
目录 :
904801
克隆 :
1E8
产品 :
纯化角蛋白8单克隆抗体
抗体亚型 :
Mouse IgG2a, κ
其他名称 :
Keratin, type II cytoskeletal 8, CK-8, keratin-8, cytokeratin-8
规格 :
250微升
价格(美元) :
374美元
反应物种 :
人类
克隆性 :
单克隆
宿主 :
小鼠
共轭标签/标签/标记 :
PURE
免疫原 :
Antibody 1E8 was raised against the 12 carboxy-terminal amino acids of HK-8 preceded by a cysteine, CKLVSESSDVLPK.
更多信息或购买 :
公司信息
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。