产品简要
公司名称 :
Biosensis
产品类型 :
抗体
产品名称 :
Rabbit antibody to the Tyrosine Kinase Receptor B (TrkB; 23-36): whole serum
目录 :
R-121-100
规格 :
100微升
价格 :
297美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
反应物种 :
人类, 大鼠
更多信息或购买 :
Biosensis 产品网页
文章摘录数: 2
参考文献
Brock J, Rosenzweig E, Blesch A, Moseanko R, Havton L, Edgerton V, et al. Local and remote growth factor effects after primate spinal cord injury. J Neurosci. 2010;30:9728-37 pubmed 出版商
Gruber H, Ingram J, Hoelscher G, Zinchenko N, Norton H, Hanley E. Brain-derived neurotrophic factor and its receptor in the human and the sand rat intervertebral disc. Arthritis Res Ther. 2008;10:R82 pubmed 出版商
产品信息
目录代码 :
R-121-100
产品名称 :
Rabbit antibody to the Tyrosine Kinase Receptor B (TrkB; 23-36): whole serum
宿主物种 :
兔
克隆性 :
多克隆
产品类型 :
Whole Serum
规格 :
100微升
标价 :
297美元
Pubmed号列表 :
18637190, 20660255
产品描述 :
FUNCTION: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds APS. Interacts with SQSTM1. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. ALTERNATIVE PRODUCTS: 3 named isoforms produced by alternative splicing. Additional isoforms seem to exist. TISSUE SPECIFICITY: The different forms are differentially expressed in various cell types. Isoform T2 is primarily expressed in neurons. PTM: Ligand-mediated auto-phosphorylation. SIMILARITY: Belongs to the Tyr protein kinase family. Insulin receptor subfamily. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 2 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 protein kinase domain.
交叉活性 :
This antiserum recognises human and rat TrkB. Cross reactivity with other species has not yet been tested.
别名 :
Tropomyosin-related kinase receptor; BDNF/NT-3 growth factors receptor; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; GP145-TrkB/GP95-TrkB; Trk-B; Ntrk2; Trkb
免疫原 :
A synthetic peptide (AFPRLEPNSIDPENC) as part of rat mature TrkB protein (aa: 23-36) conjugated to KLH
特异性 :
Sequence was chosen to avoid cross reactivity with TrkA and TrkC.
包装 :
Small box at room temperature
应用摘要 :
IHC. A dilution of 1:1000 to 1:3000 is recommended for this application. The sequence of the immunogen and the conjugate are identical to the one used by Yan et al (see the Refs) and the antiserum appears to have similar characteristics. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
储存 :
After reconstitution keep aliquots at -20ºC for a higher stability, and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
产品引用 :
1. Gruber H. et al (2008) Brain-derived neurotrophic factor and its receptor in the human and the sand rat intervertebral disc. Arthritis Res Ther. 2008; 10(4): R82. . 2. Brock JH et al (2010) Local and remote growth factor effects after primate spinal cord injury. J Neurosci. 2010 Jul 21;30(29):9728-37. .
产品编号 :
198
更多信息或购买 :
Biosensis 产品网页
公司信息
Biosensis
39 Winwood Street, Thebarton, South Australia, 5031
info@biosensis.com
www.biosensis.com
61 8 83527711
公司总部: 澳大利亚
Biosensis specializes in antibodies, proteins, ELISA kits and Staining kits for Neuroscience, with particular emphasis on neurotrophins and neurotrophin receptors for which Biosensis has been the worldwide leader and OEM supplier for nearly 30 years. In addition to neurotrophins, our neuroscience portfolio includes products for research in neurodegenerative diseases, neurodevelopment, and neuro-metabolism. Areas of focus include Alzheimer's, Parkinson's and ALS diseases, as well as autophagy and metabolic and stress disorders including metabolic syndrome research, obesity, and neuroimmunology and inflammation.