产品简要
公司名称 :
Biosensis
产品类型 :
抗体
产品名称 :
Rabbit antibody to the Tyrosine Kinase Receptor A (TrkA): whole serum
目录 :
R-152-100
规格 :
100微升
价格 :
297美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
反应物种 :
人类, 大鼠
应用 :
免疫组化
更多信息或购买 :
Biosensis 产品网页
文章摘录数: 1
参考文献
Kobayashi K, Ando M, Saito Y, Kondo K, Omura G, Shinozaki Ushiku A, et al. Nerve Growth Factor Signals as Possible Pathogenic Biomarkers for Perineural Invasion in Adenoid Cystic Carcinoma. Otolaryngol Head Neck Surg. 2015;153:218-24 pubmed 出版商
产品信息
目录代码 :
R-152-100
产品名称 :
Rabbit antibody to the Tyrosine Kinase Receptor A (TrkA): whole serum
宿主物种 :
兔
克隆性 :
多克隆
产品类型 :
Whole Serum
规格 :
100微升
标价 :
297美元
产品描述 :
TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: Cell membrane; single-pass type I membrane protein. Endocytosed to the endosomes upon treatment of cells with NGF. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. Both isoforms have similar biological properties. TISSUE SPECIFICITY: Isoform TrkA-II is primarily expressed in neuronal cells. Isoform TrkA-I is found in non-neuronal tissues. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutalating behaviour, mental retardation and cancer.
交叉活性 :
Reacts with human, rat and mouse TrkA. Other species not yet tested.
别名 :
Tropomyosin-related kinase receptor; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1 transforming tyrosine kinase protein; p140-TrkA; Trk-A; NTRK1; TRK;
免疫原 :
Extracellular domain of glycosylated human TrkA protein produced in CHO cells was used as the immunogen.
特异性 :
Specificity was demonstrated by immunohistochemistry. When used for immunohistochemistry in rat dorsal root ganglia, staining is restricted to the known distribution of TrkA, that is in small, nociceptive neurons.
包装 :
Small box at room temperature
应用摘要 :
IHC, 1-site ELISA (1:5000 dilution). A dilution of 1:1000 is recommended for IHC. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
储存 :
After reconstitution keep aliquots at -20ºC for a higher stability, and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
产品编号 :
224
更多信息或购买 :
Biosensis 产品网页
公司信息
Biosensis
39 Winwood Street, Thebarton, South Australia, 5031
info@biosensis.com
www.biosensis.com
61 8 83527711
公司总部: 澳大利亚
Biosensis specializes in antibodies, proteins, ELISA kits and Staining kits for Neuroscience, with particular emphasis on neurotrophins and neurotrophin receptors for which Biosensis has been the worldwide leader and OEM supplier for nearly 30 years. In addition to neurotrophins, our neuroscience portfolio includes products for research in neurodegenerative diseases, neurodevelopment, and neuro-metabolism. Areas of focus include Alzheimer's, Parkinson's and ALS diseases, as well as autophagy and metabolic and stress disorders including metabolic syndrome research, obesity, and neuroimmunology and inflammation.