产品简要
公司名称 :
Biosensis
产品类型 :
抗体
产品名称 :
Sheep antibody to rh BDNF: IgG
目录 :
S-015-500
规格 :
500微克
价格 :
297美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化
更多信息或购买 :
文章摘录数: 2
参考文献
Hayashida K, Eisenach J. Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function. Anesthesiology. 2010;113:406-12 pubmed 出版商
Geremia N, Pettersson L, Hasmatali J, Hryciw T, Danielsen N, Schreyer D, et al. Endogenous BDNF regulates induction of intrinsic neuronal growth programs in injured sensory neurons. Exp Neurol. 2010;223:128-42 pubmed 出版商
产品信息
目录代码 :
S-015-500
产品名称 :
Sheep antibody to rh BDNF: IgG
宿主物种 :
克隆性 :
多克隆
产品类型 :
纯化
规格 :
500微克
标价 :
297美元
Pubmed号列表 :
20613480, 19646438
产品描述 :
BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. Post translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.
交叉活性 :
Known to react with BDNF from rat and human.
别名 :
Brain-derived neurotrophic factor; Abrineurin; proBDNF;
免疫原 :
重组人类BDNF
特异性 :
A cross reactivity of less than 1% against mouse NGF, recombinant human NT3 or NT4/5 has been shown by one site ELISA.
包装 :
Small box at room temperature
应用摘要 :
IHC, ELISA, WB, inhibition of biological activity in vitro/in vivo. Recommended to be used at an amount of 1-10 µg/ml for immunohistochemistry, ELISA, Western blot or inhibition of biological activity in vitro. Use neat for in vivo studies at 2-10 µg/ml (ED50). Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
储存 :
After reconstitution keep aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
产品引用 :
1. Hayashida K., Eisenach J.C.(2010) Spinal alpha2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function Anesthesiology. 2010 Aug;113(2):406-12. . 2. Geremia N.M. et al (2010) Endogenous BDNF regulates induction of intrinsic neuronal growth programs in injured sensory neurons Exp Neurol. 2010 May;223(1):128-42. .
产品编号 :
61
更多信息或购买 :
公司信息
Biosensis
39 Winwood Street, Thebarton, South Australia, 5031
info@biosensis.com
www.biosensis.com
61 8 83527711
公司总部: 澳大利亚
Biosensis specializes in antibodies, proteins, ELISA kits and Staining kits for Neuroscience, with particular emphasis on neurotrophins and neurotrophin receptors for which Biosensis has been the worldwide leader and OEM supplier for nearly 30 years. In addition to neurotrophins, our neuroscience portfolio includes products for research in neurodegenerative diseases, neurodevelopment, and neuro-metabolism. Areas of focus include Alzheimer's, Parkinson's and ALS diseases, as well as autophagy and metabolic and stress disorders including metabolic syndrome research, obesity, and neuroimmunology and inflammation.