产品简要
公司名称 :
Bioss
产品类型 :
抗体
产品名称 :
HIF-1甲多克隆抗体
目录 :
bs-0737R
规格 :
100微升
价格 :
289.5美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 9
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 大鼠
Yang J, Lu Y, Guo A. Platelet-rich plasma protects rat chondrocytes from interleukin-1?-induced apoptosis. Mol Med Rep. 2016;14:4075-4082 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Madka V, Mohammed A, Li Q, Zhang Y, Biddick L, Patlolla J, et al. Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo. Cancer Prev Res (Phila). 2016;9:53-62 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 1
  • 免疫印迹; 人类; 图 5
Yang Y, Li M, Yan Y, Zhang J, Sun K, Qu J, et al. Expression of RAP1B is associated with poor prognosis and promotes an aggressive phenotype in gastric cancer. Oncol Rep. 2015;34:2385-94 pubmed 出版商
  • 免疫印迹; 小鼠
Woolf E, Curley K, Liu Q, Turner G, Charlton J, Preul M, et al. The Ketogenic Diet Alters the Hypoxic Response and Affects Expression of Proteins Associated with Angiogenesis, Invasive Potential and Vascular Permeability in a Mouse Glioma Model. PLoS ONE. 2015;10:e0130357 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Zhang H, Ren Y, Tang X, Wang K, Liu Y, Zhang L, et al. Vascular normalization induced by sinomenine hydrochloride results in suppressed mammary tumor growth and metastasis. Sci Rep. 2015;5:8888 pubmed 出版商
  • 免疫印迹; 大鼠
Guo W, Feng J, Yao L, Sun L, Zhu G. Transplantation of endothelial progenitor cells in treating rats with IgA nephropathy. BMC Nephrol. 2014;15:110 pubmed 出版商
  • 免疫印迹; 小鼠
Fan S, Xu Y, Li X, Tie L, Pan Y, Li X. Opposite angiogenic outcome of curcumin against ischemia and Lewis lung cancer models: in silico, in vitro and in vivo studies. Biochim Biophys Acta. 2014;1842:1742-54 pubmed 出版商
  • 免疫印迹; 人类
Shou Z, Lin L, Liang J, Li J, Chen H. Expression and prognosis of FOXO3a and HIF-1? in nasopharyngeal carcinoma. J Cancer Res Clin Oncol. 2012;138:585-93 pubmed 出版商
Talwar H, Bauerfeld C, Bouhamdan M, Farshi P, Liu Y, Samavati L. MKP-1 negatively regulates LPS-mediated IL-1β production through p38 activation and HIF-1α expression. Cell Signal. 2017;34:1-10 pubmed 出版商
产品信息
SKU号 :
bs-0737R
名称 :
HIF-1甲多克隆抗体
类别 :
一抗
共轭 :
未共轭
宿主 :
靶蛋白 :
HIF-1甲
修饰 :
Unmodified
克隆性 :
多克隆
抗体亚型 :
IgG
浓度 :
1微克/微升
public immunogen range :
351-400/826
subcellular locations :
Cytoplasm, Nucleus
来源 :
KLH合成多肽共轭人人的HIF-1甲
基因编号链接 :
Entrez Gene: 3091
Swiss Prot数据库 :
Q16665
Swiss Prot数据库链接 :
Swiss Prot: Q16665
应用 :
免疫印迹, 免疫组化-P, IF(免疫组化-P), IF(免疫细胞化学)
applications with dilutions :
免疫印迹(1:100-1000), 免疫组化-P(1:100-500), IF(免疫组化-P)(1:50-200), IF(免疫细胞化学)(1:50-200)
cross reactive species :
人类, 小鼠, 大鼠
规格 :
100微升
价格 :
289.5美元
背景 :
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 4 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP3. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
纯化 :
Purified by Protein A.
储存 :
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
同义词 :
HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; Hypoxia-inducible factor 1-alpha; HIF-1-alpha; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; Member of PAS protein 1; PAS domain-containing protein 8; HIF1A
铅时间 :
3 to 5 business days.
更多信息或购买 :
公司信息
Bioss
500 West Cummings Park
Suite 6500
Woburn, MA 01801
info@biossusa.com
biossusa.com
010-88798567
公司总部: 美国
Bioss Inc is a leading antibody developer and manufacturer with state of the art technologies. We have developed over 11,000 antigens/primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.