产品简要
公司名称 :
Bioss
产品类型 :
抗体
产品名称 :
Livin Polyclonal Antibody
目录 :
bs-0738R
规格 :
100微升
价格 :
289.5美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 1
产品信息
SKU号 :
bs-0738R
名称 :
Livin Polyclonal Antibody
类别 :
一抗
共轭 :
未共轭
宿主 :
兔
靶蛋白 :
Livin
修饰 :
Unmodified
克隆性 :
多克隆
抗体亚型 :
IgG
浓度 :
1微克/微升
public immunogen range :
100-150/298
subcellular locations :
Cytoplasm, Nucleus
来源 :
KLH conjugated synthetic peptide derived from human Livin
基因编号链接 :
Entrez Gene: 79444
Swiss Prot数据库 :
Q96CA5
Swiss Prot数据库链接 :
Swiss Prot: Q96CA5
应用 :
免疫印迹, 免疫组化-P, IF(免疫组化-P)
applications with dilutions :
免疫印迹(1:100-1000), 免疫组化-P(1:100-500), IF(免疫组化-P)(1:50-200)
cross reactive species :
人类, 小鼠, 大鼠
规格 :
100微升
价格 :
289.5美元
背景 :
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.
纯化 :
Purified by Protein A.
储存 :
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
同义词 :
KIAP; LIVIN; MLIAP; RNF50; ML-IAP; Baculoviral IAP repeat-containing protein 7; Kidney inhibitor of apoptosis protein; Melanoma inhibitor of apoptosis protein; RING finger protein 50; BIRC7; UNQ5800/PRO19607/PRO21344
铅时间 :
3 to 5 business days.
更多信息或购买 :
公司信息
Bioss
500 West Cummings Park
Suite 6500
Woburn, MA 01801
Suite 6500
Woburn, MA 01801
info@biossusa.com
biossusa.com010-88798567
公司总部: 美国
Bioss Inc is a leading antibody developer and manufacturer with state of the art technologies. We have developed over 11,000 antigens/primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.