产品简要
公司名称 :
Bioss
产品类型 :
抗体
产品名称 :
雌激素受体α(S167)抗体
目录 :
bs-0894R
规格 :
100微升
价格 :
299美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫印迹, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
SKU号 :
bs-0894R
名称 :
雌激素受体α(S167)抗体
类别 :
一抗
共轭 :
未共轭
宿主 :
靶蛋白 :
雌激素受体αSer167
修饰 :
磷酸化
修饰位点 :
Ser167
克隆性 :
多克隆
抗体亚型 :
IgG
浓度 :
1微克/微升
public immunogen range :
150-175/595
subcellular locations :
Nucleus
来源 :
KLH conjugated synthetic phosphopeptide derived from human Estrogen Receptor alpha around the phosphorylation site of Ser167
基因编号链接 :
Entrez Gene: 2099
Swiss Prot数据库 :
P03372
Swiss Prot数据库链接 :
Swiss Prot: P03372
应用 :
免疫印迹, 免疫组化-P, IF(免疫组化-P)
applications with dilutions :
免疫印迹(1:100-1000), 免疫组化-P(1:100-500), IF(免疫组化-P)(1:50-200)
cross reactive species :
人类
规格 :
100微升
价格 :
299美元
背景 :
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.
纯化 :
Purified by Protein A.
储存 :
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
同义词 :
ER; ESR; Era; ESRA; ESTRR; NR3A1; Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1; ESR1
铅时间 :
3 to 5 business days.
更多信息或购买 :
公司信息
Bioss
500 West Cummings Park
Suite 6500
Woburn, MA 01801
info@biossusa.com
biossusa.com
010-88798567
公司总部: 美国
Bioss Inc is a leading antibody developer and manufacturer with state of the art technologies. We have developed over 11,000 antigens/primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.