ELISA/assay

Mouse mAb anti- human Tumor Necrosis Factor alpha (TNF-α), Tracer (HRP Labeled), Clone B1E4

BA010038

0.2毫升

420.00美元

Mouse mAb anti- human Tumor Necrosis Factor alpha (TNF-α), Tracer (HRP Labeled), Clone B1E4

Matched Antibody Pairs

小鼠

单克隆

B1E4

IgG1, k

0.2毫升

420.00美元

P01375

辣根过氧化物酶(HRP)共轭标签小鼠单克隆抗体人类肿瘤坏死因子α(TNF-)

Human, other species not tested

Tumor Necrosis Factor alpha (TNF-α) is a multifunctional pro-inflammatory cytokine, mainly secreted by activated macrophages. TNF-α was named for its remarkable ability to cause hemorrhagic necrosis of tumors in mice. It is implicated with a variety of biological procedures including systemic inflammation, cell proliferation, apoptosis, lipid metabolism, and coagulation. The pleiotropic attribute of TNF-α regulation is associated with its ability to trigger multiple signalling pathways simultaneously. It is well documented that TNF-α functions through its receptors, TNFR1 (p55) and TNFR2 (p75). TNF-α not only contributes to the immune response to bacterial, fungal, viral and parasitic invasions, but also functions in tissue remodeling, autoimmune-diseases and the necrosis of specific tumors. TNF-α hyper-expression in response to some bacterial components such as LPS can cause life threatening septic shock. Recombinant TNF-α, in combination with chemotherapy, has been applied for treatment of soft sarcomas, melanomas and other irresectable tumors. Anti-TNF-α therapy has been used for treatment of rheumatoid arthritis.

纯化重组人类TNF-α

这抗体反应对象人类TNF-α

蛋白质G亲和纯化

0.01M PBS, pH值7.2, 含50% 甘油

ELISA: This HRP-conjugated monoclonal antibody can be used as a tracer/detection antibody in sandwich ELISA applications for human TNF-α detection in combination with capture antibody CH8820 (Cat. No.: MO-C40003B) and avidin-HRP conjugate.

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