抗体

小鼠单克隆抗体抗人类肿瘤坏死因子α(TNF-α), 克隆C5G7

BA010090

0.5毫克

378.00美元

单克隆

小鼠

未共轭

C5G7

小鼠单克隆抗体抗人类肿瘤坏死因子α(TNF-α), 克隆C5G7

单克隆抗体

小鼠

单克隆

C5G7

IgG1, k

0.5毫克

378.00美元

P01375

小鼠单克隆抗体人类肿瘤坏死因子α(TNF-α)

Human, other species not tested

Tumor Necrosis Factor-alpha (TNF-α) is a multifunctional pro-inflammatory cytokine, mainly secreted by activated macrophages. TNF-α was named for its remarkable ability to cause hemorrhagic necrosis to tumors in mice. It is implicated with a variety of biological procedures including systemic inflammation, cell proliferation, apoptosis, lipid metabolism, and coagulation. The pleiotropic attribute of TNF-α regulation is associated with its ability to trigger multiple signalling pathways simultaneously. It is well documented that TNF-α functions through its receptors, TNFR1 (p55) and TNFR2 (p75). TNF-α not only contributes to the immune response to bacterial, fungal, viral and parasitic invasions, but also functions in tissue remodeling, autoimmune-diseases and the necrosis of specific tumors. TNF-α hyper-expression in response to some bacterial components such as LPS can cause life threatening septic shock. Recombinant TNF-α, in combination with chemotherapy, has been applied for treatment of soft sarcomas, melanomas and other irresectable tumors. Anti-TNF-α therapy has been used for treatment of rheumatoid arthritis.

纯化重组人类TNF-α

这抗体反应对象人类TNF-α

冻干来自a溶液在0.01M PBS, pH值7.0

ELISA:反应对象TNF-α。 免疫印迹

存放在-20°C