抗体

小鼠单克隆抗体抗人类转化生长因子β(TGF-β), 克隆2C5

BA010097

0.5毫克

378.00美元

单克隆

小鼠

未共轭

2C5

小鼠单克隆抗体抗人类转化生长因子β(TGF-β), 克隆2C5

单克隆抗体

小鼠

单克隆

2C5

IgG1, k

0.5毫克

378.00美元

P01137

小鼠单克隆抗体人类转化生长因子β(TGF-β)

Human, other species not tested

Transforming growth factor beta (TGF-β) has three isoforms (TGF-β1, TGF-β2, and TGF-β3) with similar functions. The cytokine is a homodimer linked by disulfide bind. Inside cells, the cytokine forms a small latent complex with latent associated peptide (LAP). This small complex binds to latent TGF-β binding protein (LTBP) to be secreted to extra-cellular matrix. Disassociation of the latent proteins from TGF-β results in the release of the cytokine to its receptor. The process is called activation, which can be influenced by various factors, including proteases, metalloproteases, extreme pH, mild acidic condition, reactive oxygen species and integrins. TGF-β is an anti-proliferation factor in normal cells. It increases the synthesis of p15 and p21, which can block the cyclin: CDK complex, and causes cells to stop at G1 phase. The cytokine can induce apoptosis through both SMAD and DAXX pathways. In cancer cells, TGF-β signaling is altered and TGF-β no longer stops cell proliferation.

TGF-β来自人类血小板

这抗体反应对象人类TGF-β

蛋白质G亲和纯化

冻干来自a溶液在0.01M PBS, pH值7.0

ELISA: The antibody reacts with TGF-β. Western Blot: This antibody when used at concentration of 5-20ng/mL will allow visualization of 100ng/lane of TGF-β.

存放在-20°C