抗体

AKT1小鼠单克隆抗体IgG2b

BA110022

100微升

279美元

单克隆

小鼠

未共轭

D9-9-C9

人类, 小鼠

免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪

抗体

AKT1小鼠单克隆抗体IgG2b

BA110022-100µl

279美元

100微升

多肽

免疫印迹, 免疫细胞化学, 免疫组化, FC

RAC-alpha serine/threonine-protein kinase,Protein kinase B,Protein kinase B alpha,Proto-oncogene c-Akt,RAC-PK-alpha

The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mice lacking Akt1 display a 25% reduction in body mass, indicating that Akt1 is critical for transmitting growth-promoting signals, most likely via the igf1 receptor. Mice lacking Akt1 are also resistant to cancer: They experience considerable delay in tumor growth initiated by the large T antigen or the Neuoncogene.(EM40507)

单克隆

D9-9-C9

P31749

ProA affinity purified

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

小鼠

人类, 小鼠