抗体

CD3 zeta Rabbit polyclonal Antibody IgG

BA110149

100微升

279美元

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫细胞化学, 流式细胞仪

抗体

CD3 zeta Rabbit polyclonal Antibody IgG

BA110149-100µl

279美元

100微升

This antibody is produced by immunizing rabbits with a synthetic Peptide (KLH-coupled) corresponding to a region of C-terminal residues of CD3 zeta.

免疫印迹, 免疫细胞化学, FC

T-cell surface glycoprotein CD3 zeta chain,T-cell receptor T3 zeta chain,CD_antigen: CD247

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN).(0805-7)

多克隆

P20963

免疫原亲和纯化

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

兔

人类, 小鼠, 大鼠