抗体

GRP78 BiP Mouse monoclonal Antibody IgG1

BA110321

100微升

279美元

单克隆

小鼠

未共轭

C9-9

人类, 小鼠, 斑马鱼

免疫印迹, 免疫组化, 免疫细胞化学

抗体

GRP78 BiP Mouse monoclonal Antibody IgG1

BA110321-100µl

279美元

100微升

重组蛋白

免疫印迹, 免疫细胞化学, 免疫组化

78 kDa glucose-regulated protein,Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78,Heat shock 70 kDa protein 5,Immunoglobulin heavy chain-binding protein

Binding immunoglobulin protein (BiP) also known as 78 kDa glucose-regulated protein (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) is a protein that in humans is encoded by the HSPA5 gene. BiP is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum (ER) that binds newly synthesized proteins as they are translocated into the ER, and maintains them in a state competent for subsequent folding and oligomerization. BiP is also an essential component of the translocation machinery, as well as playing a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome. Like many stress and heat shock proteins, BiP/GRP78 has potent immunological activity when released from the internal environment of the cell into the extracelluar space.specifically, it feeds anti-inflammatory and pro-resolutory signals into immune networks, thus helping to resolve inflammation.(M1506-2)

单克隆

C9-9

P11021

ProA affinity purified

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

小鼠

人类, 小鼠, 斑马鱼