抗体

HSP27小鼠单克隆抗体IgG2b

BA110357

100微升

279美元

单克隆

小鼠

未共轭

10-8

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学

抗体

HSP27小鼠单克隆抗体IgG2b

BA110357-100µl

279美元

100微升

重组蛋白

免疫印迹, 免疫细胞化学, 免疫组化

Heat shock protein beta-1,28 kDa heat shock protein,Estrogen-regulated 24 kDa protein,Heat shock 27 kDa protein,Stress-responsive protein 27

Hsp27 is a chaperone of the sHsp(small heat shock protein) group among ubiquitin, α-crystallin, Hsp20 and others. The common functions of sHsps are chaperone activity, thermotolerance, inhibition of apoptosis, regulation of cell development, and cell differentiation. They also take part in signal transduction. The main function of Hsp27 is to provide thermotolerance in vivo, cytoprotection, and support of cell survival under stress conditions. More specialized functions of Hsp27 are manifold and complex. In vitro it acts as an ATP-independent chaperone by inhibiting protein aggregation and by stabilizing partially denatured proteins, which ensures refolding by the Hsp70-complex. Hsp27 is also involved in the apoptotic signalling pathway. Hsp27 interacts with the outer mitochondrial membranes and interferes with the activation of cytochrome c/Apaf-1/dATP complex and therefore inhibits the activation of procaspase-9.(M1505-3)

单克隆

10-8

P04792

ProA affinity purified

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

小鼠

人类, 小鼠, 大鼠