抗体

HLA-DR小鼠单克隆抗体IgG1

BA110812

100微升

279美元

单克隆

小鼠

未共轭

10-D8

免疫印迹, 免疫组化, 流式细胞仪

抗体

HLA-DR小鼠单克隆抗体IgG1

BA110812-100µl

279美元

100微升

多肽

免疫印迹, 免疫组化, FC

HLA组织相容性抗原II类, DR甲链, MHC II类抗原DRA

Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in mhc ii-a/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (β-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.(M1701-5)

单克隆

10-D8

P01903(人类)

肽亲和纯化

1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.

小鼠

人类