抗体

Tim3兔多克隆抗体IgG

BA110827

100微升

279美元

多克隆

domestic rabbit

未共轭

人类, 小鼠

免疫印迹, 免疫组化, 免疫细胞化学

抗体

Tim3兔多克隆抗体IgG

BA110827-100µl

279美元

100微升

多肽

免疫印迹, 免疫细胞化学, 免疫组化

Hepatitis A virus cellular receptor 2, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3

Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse.(R1706-6)

多克隆

Q8TDQ0(人类)Q8VIM0(小鼠)

肽亲和纯化

1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.

兔

人类, 小鼠