抗体

多聚(ADP-核糖)聚合酶小鼠单克隆抗体IgG1

BA110862

100微升

279美元

单克隆

小鼠

未共轭

A0-D11

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪

抗体

多聚(ADP-核糖)聚合酶小鼠单克隆抗体IgG1

BA110862-100µl

279美元

100微升

多肽

免疫印迹, 免疫细胞化学, 免疫组化, FC

Poly [ADP-ribose] polymerase 1, ADP-ribosyltransferase diphtheria toxin-like 1, NAD(+) ADP-ribosyltransferase 1, Poly[ADP-ribose] synthase 1

Poly(ADP-ribose) polymerase-1 (PARP-1), also designated PARP, is a nuclear DNA-binding zinc finger protein that influences DNA repair, DNA replication, modulation of chromatin structure, and apoptosis. In response to genotoxic stress, PARP-1 catalyzes the transfer of ADP-ribose units from NAD(+) to a number of acceptor molecules including chromatin. PARP-1 recognizes DNA strand interruptions and can complex with RNA and negatively regulate transcription. Actinomycin D- and etoposide-dependent induction of caspases mediates cleavage of PARP-1 into a p89 fragment that traverses into the cytoplasm. Apoptosis-inducing factor (AIF) translocation from the mitochondria to the nucleus is PARP-1-dependent and is necessary for PARP-1-dependent cell death. PARP-1 deficiencies lead to chromosomal instability due to higher frequencies of chromosome fusions and aneuploidy, suggesting that poly(ADP-ribosyl)ation contributes to the efficient maintenance of genome integrity.(EM1701-16)

单克隆

A0-D11

P09874(人类)P11103(小鼠)P27008(大鼠)

肽亲和纯化

1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.

小鼠

人类, 小鼠, 大鼠