抗体

Tyk2兔多克隆抗体IgG

BA111144

100微升

279美元

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪

抗体

Tyk2兔多克隆抗体IgG

BA111144-100µl

279美元

100微升

Recombinant protein within human TYK2 aa 400-600.

免疫印迹, 免疫细胞化学, 免疫组化, FC

Non-receptor tyrosine-protein kinase TYK2

TYK2 belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions occurring downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, recruit STAT transcription factors to the cytokine receptor where TYK2 is associated. TYK2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulating transcription. The canonical JAK-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Cytokine induced pro-inflammatory responses are attractive targets for anti-inflammatory therapies, specifically at the level of Jak-STAT signaling.(ER1803-05)

多克隆

P29597(人类)Q9R117(小鼠)

蛋白亲和纯化

1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.

兔

人类, 小鼠, 大鼠