抗体

HLA Class 1 ABC Mouse monoclonal Antibody IgG1

BA111231

100微升

279美元

单克隆

小鼠

未共轭

11C3

免疫印迹, 免疫细胞化学

抗体

HLA Class 1 ABC Mouse monoclonal Antibody IgG1

BA111231-100µl

279美元

100微升

Recombinant protein within Human HLA Class 1 ABC aa 120-310.

免疫印迹, 免疫细胞化学

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.(EM1801-09)

单克隆

11C3

SwissProt: P01889 Human SwissProt: P30443 Human SwissProt: P30499 Human

蛋白亲和纯化

1*TBS (pH7.4), 1%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.

小鼠

人类