抗体

Ras Recombinant Rabbit monoclonal Antibody IgG

BA111291

100微升

279美元

单克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠, 斑马鱼

免疫印迹, 免疫沉淀, 流式细胞仪

抗体

Ras Recombinant Rabbit monoclonal Antibody IgG

BA111291-100µl

279美元

100微升

重组蛋白

免疫印迹, 免疫沉淀, FC

GTPase Nras, GTPase Hras, GTPase Kras

Ras superfamily is a protein superfamily of small GTPases, which are all related, to a degree, to the Ras protein subfamily (the key human members of which are KRAS, NRAS, and HRAS). Receptor tyrosine kinases and G protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway. GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, research studies have shown that in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway. The most common oncogenic Ras mutation found in tumors is Gly12 to Asp12 (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein. This antibody is predicted to react with H-Ras, N-Ras and K-Ras.(ET1601-16)

单克隆

P01111(人类)P01112(人类)P01116(人类)P08556(小鼠)P32883(小鼠)Q61411(小鼠)P08644(大鼠)P20171(大鼠)Q04970(大鼠)

ProA affinity purified

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

兔

人类, 小鼠, 大鼠, 斑马鱼