抗体

ERK1/2重组兔单克隆抗体IgG

BA111305

100微升

279美元

单克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠, 斑马鱼

免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪

抗体

ERK1/2重组兔单克隆抗体IgG

BA111305-100µl

279美元

100微升

重组蛋白

免疫印迹, 免疫细胞化学/IF, 免疫沉淀, FC

Mitogen-activated protein kinase 3, ERT2, Extracellular signal-regulated kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-ERK1, Mitogen-activated protein kinase 1, ERT1, Extracellular signal-regulated kinase 2, MAP kinase isoform p42, Mitogen-activated protein kinase 2

Mitogen-activated protein kinase (MAPK) signaling pathways involve two closely related MAP kinases, known as extracellular-signal-related kinase 1 (ERK 1, p44) and 2 (ERK 2, p42). Growth factors, steroid hormones, G protein-coupled receptor ligands and neurotransmitters can initiate MAPK signaling pathways. Activation of ERK 1 and ERK 2 requires phosphorylation by upstream kinases such as MAP kinasekinase (MEK), MEK kinase and Raf-1. ERK 1 and ERK 2 phosphorylation can occur at specific tyrosine and threonine sites mapping within consensus motifs that include the threonine-glutamate-tyrosine motif. ERK activation leads to dimerization with other ERKs and subsequent localization to the nucleus. Active ERK dimers phosphorylate serine and threonine residues on nuclear proteins and influence a host of responses that include proliferation, differentiation, transcription regulation and development. The human ERK 1 gene maps to chromosome 16p11.2 and encodes a 379 amino acid protein that shares 83% sequence identity to ERK 2. The human ERK2 gene maps to chromosome 22q11.21 and encodes a 360-amino acid protein.(ET1601-29)

单克隆

P27361(人类)P28482(人类)P63085(小鼠)Q63844(小鼠)P21708(大鼠)P63086(大鼠)

ProA affinity purified

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

兔

人类, 小鼠, 大鼠, 斑马鱼