抗体

磷酸化STAT3(Tyr705)重组兔单克隆抗体IgG

BA111382

100微升

279美元

单克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀

抗体

磷酸化STAT3(Tyr705)重组兔单克隆抗体IgG

BA111382-100µl

279美元

100微升

Synthetic phospho-Peptide corresponding to residues surrounding Tyr705 of human STAT3.

免疫印迹, 免疫细胞化学/IF, 免疫组化, 免疫沉淀

Signal transducer and activator of transcription 3, Acute-phase response factor

Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.(ET1603-40)

单克隆

P40763(人类)P42227(小鼠)P52631(大鼠)

ProA affinity purified

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

兔

人类, 小鼠, 大鼠