抗体

血小板衍生生长因子受体乙(磷酸化Y740)重组兔单克隆抗体IgG

BA111729

100微升

279美元

单克隆

domestic rabbit

未共轭

小鼠, 大鼠

免疫印迹, 免疫细胞化学

抗体

血小板衍生生长因子受体乙(磷酸化Y740)重组兔单克隆抗体IgG

BA111729-100µl

279美元

100微升

Synthetic phospho-Peptide corresponding to residues surrounding Tyr740 of human PDGF Receptor beta.

免疫印迹, 免疫细胞化学/IF

Platelet-derived growth factor receptor beta, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, CD_antigen: CD140b

Platelet Derived Growth Factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PDGF-AA, PDGF-AB, and PDGF-BB. These three isoforms bind with different affinities to two receptor types, a and b, which are endowed with protein tyrosine kinase domains and undergo either homo- or heterodimerization as a consequence of ligand binding. Ligand stimulation of PDGFR-b leads to autophosphorylation at Tyr-857, which is the major autophosphorylation site, and Tyr-751, which is the major in vitro phosphorylation site. Autophosphorylation of Tyr-751, which lies in the kinase insert region, is required for binding of phosphatidylinositol-3 kinase to the receptor. These auto-phosphorylation events largely contribute to signal transduction through the PDGF receptor.(ET1611-29)

单克隆

P05622(小鼠)Q05030(大鼠)

ProA affinity purified

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

兔

小鼠, 大鼠