抗体

磷酸化YAP1(S127)重组兔单克隆抗体IgG

BA111773

100微升

279美元

单克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化

抗体

磷酸化YAP1(S127)重组兔单克隆抗体IgG

BA111773-100µl

279美元

100微升

人类胸、乳房癌组织, 人类肾脏组织, 小鼠肾脏组织

免疫印迹, 免疫组化

Transcriptional coactivator YAP1, Protein yorkie homolog, Yes-associated protein YAP65 homolog

The Yes-associated protein, otherwise known as YAP, is a 14-3-3-binding molecule that was originally recognized by virtue of its ability to bind to the SH3 domain of Yes. The binding of YAP to 14-3-3 requires the phosphorylation of a homologous serine residue (Ser 112) in the YAP 14-3-3-binding motif. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. YAP may link events at the plasma membrane and cytoskeleton to inhibition of transcription in the nucleus in a manner regulated by 14-3-3 proteins. YAP shares homology with the WW domain of TAZ, transcriptional co-activator with PDZ-binding motif, which functions as a transcriptional co-activator by binding to the PPXY motif present in transcription factors. YAP is expressed at high levels in the lung, placenta, prostate, ovary and testis.(ET1611-69)

单克隆

P46937(人类)P46938(小鼠)Q2EJA0(大鼠)

ProA affinity purified

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

兔

人类, 小鼠, 大鼠