抗体

Ret Recombinant Rabbit monoclonal Antibody IgG

BA111804

100微升

279美元

单克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪

抗体

Ret Recombinant Rabbit monoclonal Antibody IgG

BA111804-100µl

279美元

100微升

重组蛋白

免疫印迹, 免疫细胞化学/IF, 免疫组化, 免疫沉淀, FC

Proto-oncogene tyrosine-protein kinase receptor Ret, Cadherin family member 12, Proto-oncogene c-Ret

The Ret proto-oncogene (c-Ret) is a receptor tyrosine kinase that functions as a multicomponent receptor complex in conjunction with other membrane-bound, ligand-binding GDNF family receptors. Ligands that bind the Ret receptor include the glial cell line-derived neurotrophic factor (GDNF) and its congeners neurturin, persephin, and artemin. Research studies have shown that alterations in the corresponding RET gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung’s disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr at position 905 dramatically inhibits Ret autophosphorylation activity.(ET1611-98)

单克隆

P07949(人类)P35546(小鼠)G3V9H8(大鼠)

ProA affinity purified

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

兔

人类, 小鼠, 大鼠