产品简要
公司名称 :
Bon Opus Biosciences
产品类型 :
抗体
产品名称 :
磷酸化Raf1(S259)重组兔单克隆抗体IgG
目录 :
BA111891
规格 :
100微升
价格 :
279美元
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
产品信息
目录 :
BA111891
fieldType :
抗体
名称 :
磷酸化Raf1(S259)重组兔单克隆抗体IgG
SKU号 :
BA111891-100µl
价格 :
279美元
productOptionDescription1 :
100微升
免疫原 :
Synthetic phospho-Peptide corresponding to residues surrounding Ser259 of human Raf1
应用摘要 :
免疫印迹, 免疫组化
别名 :
RAF proto-oncogene serine/threonine-protein kinase, Proto-oncogene c-RAF, Raf-1
背景 :
Raf-1 is a ubiquitously expressed cytoplasmic protein with intrinsic serine/threonine kinase activity. Raf-1, or c-Raf, is the cellular homolog of v-Raf, the product of the transforming gene of the 3611 strain of murine sarcoma virus. The unregulated kinase activity of the v-Raf protein is associated with cellular transformation and mitogenesis. Raf-1 is normally suppressed by its regulatory N-terminal domain. Raf-1 is activated in response to a variety of tyrosine kinase receptors as well as in response to pp60v-Src expression. Specifically, Raf-1 is phosphorylated in the catalytic domain at Ser 338 and, to a lesser extent, Ser 339. This phosphorylation requires the co-activation of PI 3-kinase and the Ras signaling pathway. Raf-1 is also phosphorylated on Tyr 340 and 341, which induces the phosphorylation of MEK. Phosphorylation of Ser 621 is essential for the catalytic activity of Raf-1 and downregulation by c-AMP-dependent protein kinase A (PKA). PKA also phosphorylates Raf-1 on Ser 43 and Ser 259. PKA phosphorylation of Ser 259 inhibits Raf-1 and decreases the phosphorylation necessary for Raf-1 activation at Ser 338.(ET1612-87)
Clonarity :
单克隆
登录号 :
P04049(人类)Q99N57(小鼠)P11345(大鼠)
纯化 :
ProA affinity purified
配方 :
1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
宿主物种 :
物种活性 :
人类, 小鼠, 大鼠
更多信息或购买 :
公司信息
Bon Opus Biosciences
150 Essex St. Suite 301
Millburn, NJ 07041
sales@bonopusbio.com
http://www.bonopusbio.com
1-800-943-6396
公司总部: 美国
Bon Opus Biosciences is a biotech company providing essential reagents to life science community. Bon Opus is derived from the Latin "Bonum Opus," which translates to good work. We are a team of like-minded and determined individuals, all sharing a vision for success. The catalog product includes primary antibody and recombinant proteins. The scope of services offered ranges from gene synthesis to recombinant protein expression, peptide synthesis, recombinant antibody production.

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Flat rate charge for gene synthesis, recombinant protein production
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