抗体

CD3D重组兔单克隆抗体IgG

BA111957

100微升

279美元

单克隆

domestic rabbit

未共轭

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪

抗体

CD3D重组兔单克隆抗体IgG

BA111957-100µl

279美元

100微升

重组蛋白

免疫印迹, 免疫细胞化学, 免疫组化, 免疫沉淀, FC

T-cell surface glycoprotein CD3 delta chain, T-cell receptor T3 delta chain, CD_antigen: CD3d

The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of gamma and epsilon chains (γε), a heterodimer of delta and epsilon chains (δε) and a homodimer of two zeta chains (ΩΩ) or a heterodimer of zeta and eta chains (Ωh). The Ω and h chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The γ, ε and δ chains each contain a single copy of a conserved immunoreceptor tyrosine-based activation motif (ITAM). In contrast, the Ω chain contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP-70 and Syk and are also capable of regulating their kinase activity. The crystal structure of the ZAP-70 SH2 domains bound to the Ω chain ITAMs has been solved.(ET1701-57)

单克隆

P04234(人类)

ProA affinity purified

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

兔

人类