抗体

毛细血管扩张性共济失调症突变蛋白(磷酸化S1981)重组兔单克隆抗体IgG

BA112330

100微升

279美元

单克隆

domestic rabbit

未共轭

JM93-25

人类, 小鼠

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀

抗体

毛细血管扩张性共济失调症突变蛋白(磷酸化S1981)重组兔单克隆抗体IgG

BA112330-100µl

279美元

100微升

Synthetic phospho-Peptide corresponding to residues surrounding Ser1981 of human ATM.

免疫印迹, 免疫细胞化学/IF, 免疫组化, 免疫沉淀

Serine-protein kinase ATM, Ataxia telangiectasia mutated

Serine / threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thus acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST] -Q. Phosphorylates 'Ser-139' of histone variant H2AX / H2AFX at double strand breaks (DSBs), recover equilibrium DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain Allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin , Soaccessability to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as A genre of activation of ABL1 and SAPK. May play a role in vesicle and / or protein transport. Could play A role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends.(ET1705-50)

单克隆

JM93-25

Q13315(人类)

ProA affinity purified

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

兔

人类, 小鼠