产品简要
公司名称 :
Bon Opus Biosciences
产品类型 :
ELISA/assay
产品名称 :
人类白细胞介素17A(IL-17A)酶联免疫吸附试剂盒
目录 :
BE010046
规格 :
96 well
价格 :
473.00美元
更多信息或购买 :
产品信息
目录代码 :
BE010046
产品名称 :
人类白细胞介素17A(IL-17A)酶联免疫吸附试剂盒
产品类型 :
酶联免疫吸附试剂盒
规格 :
96 well
标价 :
473.00美元
登录号 :
Q16552
背景 :
Interleukin -17A (IL-17A) is a secreted, homodimeric glycoprotein linked by disulfide link with a molecular mass of 35 KiloDalton. The cytokine is the proto-type of a newly discovered pro-inflammatory cytokine family which consists of IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (IL-25) and IL-17F. All the IL-17s have similar structure with four highly conserved cysteine residues and same 3 dimensional structures, which distinguish this family from other cytokines. IL-17 is produced by a group of CD4 T help cells termed Th17 cells. In addition to previous discovered Th1 and Th2 cells, the Th17 cells consist in the third group of T help cells. IL-23, a growth and stabilization factor was the first cytokine that was found to involve with the development of Th 17 cells. Later on, other cytokines including TGF-beta, IL-6, IL-21 were also found to contribute to the procedure. The transcription factors implicated in the procedure were identified asSTAT3, RORgt, and RORa. IL-17, like interferon-g, is a potent mediator of delayed-type reaction. IL-17 induces the secretion of many other pro-inflammatory cytokines and chemokines such as IL-6, IL-8, GM-CSF, G-CSF, TGF-beta, TNF-alpha,GRO-alpha, MCP-1, and stimulates the expression of NF-kappaB, mitogen activated protein kinase, and prostaglandings from many cell types. By stimulating cytokine production and recruiting monocytes neutrophils to site of inflammation, the cytokine exerts its effect in response to tissue damage and invasion. Excessive expression of IL-17 was found to associate with autoimmune diseases and chronic inflammatory diseases such as multiple sclerosis, rheumatoid arthritis, psoriasis, inflammatory bowel diseases, tissue allograft rejection, allergic asthma and infectious diseases at the mucosal tissue. This IL-17A ELISA is a 3.5-hour solid phase immunoassay readily applicable to measure IL-17A levels in serum, plasma, cell culture supernatant, and other biological fluids in the range of 0 to 1000 pg/mL. It showed no cross reactivity with other cytokines tested. This IL-17A ELISA is expected to be effectively used for further investigations into the relationship between IL-17A and the various conditions mentioned.
储存 :
存放在4°C。 不冻结
更多信息或购买 :
公司信息
Bon Opus Biosciences
150 Essex St. Suite 301
Millburn, NJ 07041
sales@bonopusbio.com
http://www.bonopusbio.com
1-800-943-6396
公司总部: 美国
Bon Opus Biosciences is a biotech company providing essential reagents to life science community. Bon Opus is derived from the Latin "Bonum Opus," which translates to good work. We are a team of like-minded and determined individuals, all sharing a vision for success. The catalog product includes primary antibody and recombinant proteins. The scope of services offered ranges from gene synthesis to recombinant protein expression, peptide synthesis, recombinant antibody production.

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