蛋白

Recombinant Human Mast/stem Cell Growth Factor Receptor Kit/CD117/c-kit (C-6His)

CC47

10微克;50微克;500微克;1毫克

重组蛋白

Recombinant Human Mast/stem Cell Growth Factor Receptor Kit/CD117/c-kit (C-6His)

CC47-10微克

10微克;50微克;500微克;1毫克

P10721

C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. Mature human SCF R consists of a 499 amino acid (aa) extracellular domain (ECD) with five tandem immunoglobulinlike domains, a 21 aa transmembrane segment, and a 431 aa cytoplasmic domain with the split tyrosine kinase domain. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-or Th17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.

人类细胞

Ambient

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Mast/stem cell growth factor receptor Kit; SCFR; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; KIT