蛋白

重组人类表皮生长因子受体/表皮生长因子受体/ErbB1/HER1(C-Fc)

CI54

10微克;50微克;500微克;1毫克

重组蛋白

重组人类表皮生长因子受体/表皮生长因子受体/ErbB1/HER1(C-Fc)

重组蛋白

CI54-10微克

10微克;50微克;500微克;1毫克

P00533

EGFR is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling.

人类细胞

Ambient

Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Epidermal growth factor receptor,Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1,EGFR,ERBB, ERBB1, HER1