蛋白

重组人类KRAS(G12S, N-6His)

CR65

10微克;50微克;500微克;1毫克

重组人类KRAS(G12S, N-6His)

蛋白

AAH13572.1

10微克;50微克;500微克;1毫克

43

CR65-10微克

10微克;50微克;500微克;1毫克

Recombinant Human GTPase Kras is produced by our E.coli expression system and the target gene encoding Thr2-Cys185(Gly12 Ser) is expressed with a 6His tag at the N-terminus.

大肠杆菌

K-Ras belongs to the small GTPase superfamily, Ras family. As other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. K-Ras functions as a molecular on/off switch. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. Besides essential function in normal tissue signaling, the mutation of a K-Ras gene is an essential step in the development of many cancers. Several germline K-Ras mutations have been found to be associated with Noonan syndrome[4] and cardio-facio-cutaneous syndrome. Somatic K-Ras mutations are found at high rates in Leukemias, colon cancer, pancreatic cancer and lung cancer.

Less than 0.1 ng/ug (1 EU/ug)

Lyophilized from a 0.2 um filtered solution of PBS, pH7.4

Ambient

Ki-Ras; c-K-ras; KRAS2; RASK2; CFC2