蛋白

Recombinant Human C-type lectin domain family 4 member K/CD207 (N-6His)

CU47

10微克;50微克;500微克;1毫克

Recombinant Human C-type lectin domain family 4 member K/CD207 (N-6His)

蛋白

Q9UJ71

10微克;50微克;500微克;1毫克

95

CU47-10微克

10微克;50微克;500微克;1毫克

Recombinant Human C-type lectin domain family 4 member K is produced by our expression system and the target gene encoding Tyr64-Pro328 is expressed with a N-His tag.

人类细胞

Langerin (CD207) is a type II transmembrane glycoprotein which is member K of the C-type lectin domain family. Langerin is used as a marker for Langerhans cells (LCs) which represent the immature dendritic cells in the epidermis. Langerin is necessary and sufficient for Birbeck granule formation. Human langerin sequence contains a 43 aa cytoplasmic domain, a 21 aa transmembrane domain and a 264 aa extracellular domain (ECD) that contains a coiled-coil domain and a single C-type lectin domain. Human langerin shares 68%, 62%, 71% aa identity with mouse, rat and bovine langerin ECD, respectively. Trimerization greatly increases the lectin binding affinity. Langerin internalizes endogenous proteins such as type I procollagen. Internalization by LC is thought to lead to suppression of self reactions. Langerin also mediates endocytosis of non-peptide antigens containing mannose, N-acetyl glucosamine and fucose that are expressed by mycobacteria and fungae.

Less than 0.1 ng/ug (1 EU/ug)

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4

Ambient

CD207 antigen; langerin; CD207; C-type lectin domain family 4 member K; C-type lectin domain family 4, member K