产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗p53(S9)TP53抗体
目录 :
A00001S9-1
规格 :
100微升
价格 :
512美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
多克隆
反应物种 :
人类
应用 :
免疫组化
更多信息或购买 :
产品信息
SKU号 :
A00001S9-1
产品名称 :
抗p53(S9)TP53抗体
价格 :
512美元
规格 :
100微升
克隆性 :
多克隆
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用(s) :
免疫组化
应用细节 :
IHC: 1:50~1:200
描述 :
Boster Bio Anti-p53 (S9) TP53 Antibody catalog # A00001S9-1. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
基因名称 :
TP53
UniProt数据库编号 :
P04637
形式 :
液体
Contents :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
纯化 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
储存 :
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
基因全称 :
Signal transducer and activator of transcription 3
同义词 :
Signal transducer and activator of transcription 3
蛋白名 :
Signal transducer and activator of transcription 3
分子量 :
88068分子量
Protein Function :
Signal transducer and transcription activator that
mediates cellular responses to interleukins, KITLG/SCF, LEP and
other growth factors (PubMed:10688651, PubMed:12359225,
PubMed:12873986, PubMed:15194700, PubMed:17344214,
PubMed:18242580, PubMed:23084476). Once activated, recruits
coactivators, such as NCOA1 or MED1, to the promoter region of the
target gene (PubMed:17344214). May mediate cellular responses to
activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds
to the interleukin-6 (IL-6)-responsive elements identified in the
promoters of various acute-phase protein genes (PubMed:12359225).
Activated by IL31 through IL31RA (PubMed:15194700). Acts as a
regulator of inflammatory response by regulating differentiation
of naive CD4 (+) T-cells into T-helper Th17 or regulatory T-cells
(Treg): deacetylation and oxidation of lysine residues by LOXL3,
leads to disrupt STAT3 dimerization and inhibit its transcription
activity (PubMed:28065600). Involved in cell cycle regulation by
inducing the expression of key genes for the progression from G1
to S phase, such as CCND1 (PubMed:17344214). Mediates the effects
of LEP on melanocortin production, body energy homeostasis and
lactation (By similarity). May play an apoptotic role by
transctivating BIRC5 expression under LEP activation
(PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by
inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial
role in basal beta cell functions, such as regulation of insulin
secretion (By similarity).
Subcellular Localization :
Cytoplasm. Nucleus
组织特异性 :
心, 大脑, 胎盘, 肺, 肝, 骨骼肌, 肾脏和胰腺
更多信息或购买 :
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn925.485.4527
公司总部: 美国
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