产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
Anti-Hif-1 alpha hydroxy P564 Antibody
目录 :
A00013
规格 :
100微升
价格 :
329美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化
产品信息
SKU号 :
A00013
名称 :
Anti-Hif-1 alpha hydroxy P564 Antibody
价格 :
329美元
形式 :
Liquid
宿主 :
克隆性 :
多克隆
描述 :
Anti-Hif-1 alpha hydroxy P564 Antibody validated for WB in Human.
规格 :
100微升
反应物种 :
人类;小鼠;大鼠
应用 :
免疫组化;免疫印迹
背景 :
HIF-1?? (Hypoxia-inducible factor 1??, HIF1A) is a transcription factor that mediates cellular and systemic homeostatic responses to reduced O2 availability in mammals, including angiogenesis, erythropoiesis and glycolysis. This gene was mapped to 14q21-q24. HIF-1?? transactivate genes required for energy metabolism and tissue perfusion and is necessary for embryonic development and tumor explant growth. HIF-1alpha is over expressed during carcinogenesis, myocardial infarction and wound healing. It is crucial for the cellular response to hypoxia and is frequently over expressed in human cancers, resulting in the activation of genes essential for cell survival. HIF-1?? regulates the survival and function in the inflammatory microenvironment directly. It is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen availability.
浓度 :
65 mg/mL by Refractometry
交叉活性 :
No cross reactivity with other proteins.
基因全称 :
缺氧诱导因子甲
基因名称 :
缺氧诱导因子1A
前体活性 :
Bovine; Canine; Monkey; Xenopus
protein function :
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
研究种类 :
cell biology apoptosis intracellular bcl2 family cardiovascular hypoxia hif microbiology interspecies interaction host virus interaction epigenetics and nuclear signaling transcription domain families hlh / leucine zipper hlh cell biology mitochondrial cardiovascular/immune cancer invasion/microenvironment heart cancer metabolism response to hypoxia metabolism pathways and processes mitochondrial metabolism mitochondrial markers metabolism processes types of disease cell death
subcellular localization :
Cytoplasm. Nucleus. Nucleus speckle . Colocalizes with HIF3A in the nucleus and speckles (By similarity). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia. Colocalizes with SUMO1 in the nucleus, under hypoxia.
同义词 :
Hypoxia-inducible factor 1-alpha;HIF-1-alpha;HIF1-alpha;ARNT-interacting protein;Basic-helix-loop-helix-PAS protein MOP1;Class E basic helix-loop-helix protein 78;bHLHe78;Member of PAS protein 1;PAS domain-containing protein 8;HIF1A;BHLHE78, MOP1, PASD8;
组织特异性 :
Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
UniProt数据库编号 :
Q16665
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
www.boster.com.cn
925.485.4527
公司总部: 美国
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