抗CDH1抗体 | 武汉博士德生物工程有限公司 A00063 产品信息

产品简要

公司名称 :

武汉博士德生物工程有限公司

产品类型 :

抗体

产品名称 :

抗CDH1抗体

A00063

规格 :

100微克/200微升

价格 :

290美元

克隆性 :

多克隆

宿主 :

山羊

共轭标签 :

nonconjugated

反应物种 :

人类, 小鼠, 大鼠

应用 :

免疫印迹

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产品信息

SKU号 :

A00063

名称 :

抗CDH1抗体

价格 :

290美元

免疫原 :

Synthetic peptide with sequence C-DYKINLKLMDNQNK, corresponding to the internal region of the protein sequence.

形式 :

Liquid

宿主 :

山羊

contents :

Each vial contains the specific antibody at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% BSA.

纯化 :

免疫原亲和纯化

克隆性 :

多克隆

描述 :

Goat Anti-CDH1 Antibody for CDH1 detection tested with WB in Human, Rat, Dog, Pig.

规格 :

100微克/200微升

反应物种 :

人类;大鼠

应用 :

免疫印迹

背景 :

E-Cadherin, also called Cadherin 1(CDH1), Uvomorulin or calcium-dependent ashesion protein, epithelial. E-cadherin is a Ca(2+)-dependent epithelial cell-cell adhesion molecule. Downregulation of E-cadherin expression often correlates with strong invasive potential and poor prognosis of human carcinomas. The gene spans a region of approximately 100 kb, and its location on chromosome 16q22.1. It contains 16 exons and a 65-kb-long intron 2. E-cadherin gene mutations may contribute to the development of diffusely growing gastric carcinomas. E-cadherin plays a central part in the process of epithelial morphogenesis and acts as a strong invasion suppressor in experimental tumor cell systems. The standard product used in this kit is recombinant gene expression with the molecular mass of 120KDa.

基因全称 :

钙粘蛋白1

基因名称 :

Cdh1

前体活性 :

狗;猪

protein function :

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity).

研究种类 :

signal transduction cytoskeleton / ecm cell adhesion cadherins signal transduction signaling pathway calcium signaling calcium binding proteins cancer invasion/microenvironment kits/ lysates/ other elisa kits tumor biomarkers elisa kits

subcellular localization :

Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome . Golgi apparatus, trans-Golgi network . Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane (By similarity).

同义词 :

Cadherin-1;ARC-1;Epithelial cadherin;E-cadherin;Uvomorulin;CD324;E-Cad/CTF1;E-Cad/CTF2;E-Cad/CTF3;Cdh1;

组织特异性 :

Non-neural epithelial tissues.

UniProt数据库编号 :

P09803

更多信息或购买 :

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公司信息