产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗磷酸化c(Y723)CSF1R抗体
目录 :
A00082Y723
规格 :
100微升
价格 :
380美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化
更多信息或购买 :
武汉博士德生物工程有限公司 产品网页
产品信息
SKU号 :
A00082Y723
产品名称 :
抗磷酸化c(Y723)CSF1R抗体
价格 :
380美元
规格 :
100微升
克隆性 :
多克隆
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用(s) :
免疫印迹, 免疫组化, 酶联免疫吸附测定
应用细节 :
免疫印迹1:500-1:2000.免疫组化1:100-1:300酶联免疫吸附测定1:5000
描述 :
Boster Bio Anti-Phospho-c-Fms (Y723) CSF1R Antibody catalog # A00082Y723. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
浓度 :
1毫克/毫升
基因名称 :
CSF1R
UniProt数据库编号 :
P07333
免疫原 :
Synthesized peptide derived from human c-Fms around the phosphorylation site of Y723.
形式 :
液体
Contents :
液体PBS含50% 甘油, 0.5% BSA和0.02% 叠氮化钠
纯化 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
抗体亚型 :
IgG
储存 :
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
基因全称 :
表皮生长因子受体
同义词 :
Epidermal growth factor receptor; 2.7.10.1; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; EGFR; ERBB, ERBB1, HER1;
蛋白名 :
表皮生长因子受体
分子量 :
134277分子量
Protein Function :
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Plays a role in enhancing learning and memory performance (By similarity).
Subcellular Localization :
细胞膜
组织特异性 :
Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
更多信息或购买 :
武汉博士德生物工程有限公司 产品网页
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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