抗体

抗FTO抗体

A00219

100微克/200微升

290美元

多克隆

山羊

nonconjugated

人类, 小鼠, 大鼠

抗FTO抗体

290美元

Synthetic peptide with sequence QQKPDCRPYWEKDD, corresponding to the Internal region of the protein sequence.

Liquid

山羊

Each vial contains the specific antibody at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% BSA.

免疫原亲和纯化

多克隆

Goat Anti-FTO Antibody for Fto detection tested with WB in Human, Mouse, Rat, Dog, Pig.

100微克/200微升

人类;小鼠;大鼠

免疫印迹

1毫克/毫升

Alpha-ketoglutarate-dependent dioxygenase FTO

FTO

狗;猪

Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:26458103). Has no activity towards 1- methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). In particular, it is involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746).

neuroscience neurology process metabolism cardiovascular atherosclerosis lipoprotein metabolism lipid transport diabetes associated metabolism pathways and processes metabolic signaling pathways lipid and lipoprotein metabolism types of disease diabetes obesity cancer heart disease metabolic disorders

At -20 for one year. After reconstitution, at 4 for one month. It can also be aliquotted and stored frozen at -20 for a longer time. Avoid repeated freezing and thawing.

Nucleus . Nucleus speckle .

Alpha-ketoglutarate-dependent dioxygenase FTO;1.14.11.- ;Fat mass and obesity-associated protein;FTO;KIAA1752;

Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.

Q9C0B1