武汉博士德生物工程有限公司

抗体

抗神经纤维瘤抗体

A00279

100微克/200微升

290美元

多克隆

山羊

nonconjugated

人类, 斑马鱼

免疫印迹, 免疫组化

A00279

抗神经纤维瘤抗体

290美元

Synthetic peptide with sequence C-EKSKHLQDQLK, corresponding to the internal region of the protein sequence.

Liquid

山羊

Each vial contains the specific antibody at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% BSA.

免疫原亲和纯化

多克隆

Goat Anti-Neurofibromin 2 Antibody for nf2 detection tested with WB, IHC in Zebrafish.

100微克/200微升

斑马鱼

免疫组化;免疫印迹

默林

NF2

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

neuroscience neurotransmission intracellular signaling cytoskeletal neuroscience cell adhesion proteins membrane proteins signal transduction adapters cytoplasmic epigenetics and nuclear signaling transcription cancer susceptibility tumor suppressors cancer oncoproteins/suppressors

Isoform 1: Cell projection, filopodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. In a fibroblastic cell line, isoform 1 is found homogeneously distributed over the entire cell, with a particularly strong staining in ruffling membranes and filopodia. Colocalizes with MPP1 in non-myelin-forming Schwann cells. Binds with VPRBP in the nucleus. The intramolecular association of the FERM domain with the C-terminal tail promotes nuclear accumulation. The unphosphorylated form accumulates predominantly in the nucleus while the phosphorylated form is largely confined to the non-nuclear fractions.

Merlin;Moesin-ezrin-radixin-like protein;Neurofibromin-2;Schwannomerlin;Schwannomin;NF2;SCH;

Widely expressed. Isoform 1 and isoform 3 are predominant. Isoform 4, isoform 5 and isoform 6 are expressed moderately. Isoform 8 is found at low frequency. Isoform 7, isoform 9 and isoform 10 are not expressed in adult tissues, with the exception of adult retina expressing isoform 10. Isoform 9 is faintly expressed in fetal brain, heart, lung, skeletal muscle and spleen. Fetal thymus expresses isoforms 1, 7, 9 and 10 at similar levels.

P35240